Lower limb ischemia and microrheological alterations in patients with diabetic retinopathy

Katalin Biro, Barbara Sandor, David Kovacs, Beata Csiszar, Judit Vekasi, Kinga Totsimon, Andras Toth, Katalin Koltai, Dora Endrei, Kalman Toth, Gabor Kesmarky

Research output: Article

Abstract

BACKGROUND: Diabetes mellitus is frequently associated with vascular pathologies and hemorheological disorders. METHODS: 105 patients with diabetic retinopathy (DRP) (mean age 64.64±9.01 years, 56 males, 49 females), 35 age-matched non-diabetic (mean age 61.65±7.6 years, 14 males and 21 females) and 42 young healthy volunteers (mean age 25.52±3.32 years, 22 males, 20 females) were recruited. Lower extremity artery disease (LEAD) and microcirculatory alterations were screened by hand-held Doppler, transcutaneous partial tissue oxygen tension (tcpO 2), tuning fork test, 6-minute walk test, erythrocyte aggregation and deformability. RESULTS: High prevalence of LEAD was detected in diabetic population: 55.3% fulfilled the criteria of LEAD based on ankle-brachial index; severely impaired tcpO 2 was measured in 18.6%. The results of non-invasive measurements of the diabetic patients were significantly worse than those of the control groups (p<0.05). Hemorheological disturbances could be characterized by the significantly higher erythrocyte aggregation (p<0.05) and lower erythrocyte deformability (p<0.05) in the diabetic population. CONCLUSION: Macro- and microcirculatory lower limb disorders could be revealed at high prevalence in diabetic patients with retinopathy. Measurement of tcpO 2 and hemorheological variables could be useful to discover patients at higher risk for diabetic foot complications.

Original languageEnglish
Pages (from-to)23-35
Number of pages13
JournalClinical Hemorheology and Microcirculation
Volume69
Issue number1-2
DOIs
Publication statusPublished - jan. 1 2018

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Diabetic Retinopathy
Lower Extremity
Ischemia
Erythrocyte Aggregation
Erythrocyte Deformability
Arteries
Ankle Brachial Index
Diabetic Foot
Diabetes Complications
Population
Blood Vessels
Diabetes Mellitus
Healthy Volunteers
Hand
Pathology
Oxygen
Control Groups

ASJC Scopus subject areas

  • Physiology
  • Hematology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Biro, K., Sandor, B., Kovacs, D., Csiszar, B., Vekasi, J., Totsimon, K., ... Kesmarky, G. (2018). Lower limb ischemia and microrheological alterations in patients with diabetic retinopathy. Clinical Hemorheology and Microcirculation, 69(1-2), 23-35. https://doi.org/10.3233/CH-189103

Lower limb ischemia and microrheological alterations in patients with diabetic retinopathy. / Biro, Katalin; Sandor, Barbara; Kovacs, David; Csiszar, Beata; Vekasi, Judit; Totsimon, Kinga; Toth, Andras; Koltai, Katalin; Endrei, Dora; Toth, Kalman; Kesmarky, Gabor.

In: Clinical Hemorheology and Microcirculation, Vol. 69, No. 1-2, 01.01.2018, p. 23-35.

Research output: Article

Biro, K, Sandor, B, Kovacs, D, Csiszar, B, Vekasi, J, Totsimon, K, Toth, A, Koltai, K, Endrei, D, Toth, K & Kesmarky, G 2018, 'Lower limb ischemia and microrheological alterations in patients with diabetic retinopathy', Clinical Hemorheology and Microcirculation, vol. 69, no. 1-2, pp. 23-35. https://doi.org/10.3233/CH-189103
Biro, Katalin ; Sandor, Barbara ; Kovacs, David ; Csiszar, Beata ; Vekasi, Judit ; Totsimon, Kinga ; Toth, Andras ; Koltai, Katalin ; Endrei, Dora ; Toth, Kalman ; Kesmarky, Gabor. / Lower limb ischemia and microrheological alterations in patients with diabetic retinopathy. In: Clinical Hemorheology and Microcirculation. 2018 ; Vol. 69, No. 1-2. pp. 23-35.
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AU - Totsimon, Kinga

AU - Toth, Andras

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AB - BACKGROUND: Diabetes mellitus is frequently associated with vascular pathologies and hemorheological disorders. METHODS: 105 patients with diabetic retinopathy (DRP) (mean age 64.64±9.01 years, 56 males, 49 females), 35 age-matched non-diabetic (mean age 61.65±7.6 years, 14 males and 21 females) and 42 young healthy volunteers (mean age 25.52±3.32 years, 22 males, 20 females) were recruited. Lower extremity artery disease (LEAD) and microcirculatory alterations were screened by hand-held Doppler, transcutaneous partial tissue oxygen tension (tcpO 2), tuning fork test, 6-minute walk test, erythrocyte aggregation and deformability. RESULTS: High prevalence of LEAD was detected in diabetic population: 55.3% fulfilled the criteria of LEAD based on ankle-brachial index; severely impaired tcpO 2 was measured in 18.6%. The results of non-invasive measurements of the diabetic patients were significantly worse than those of the control groups (p<0.05). Hemorheological disturbances could be characterized by the significantly higher erythrocyte aggregation (p<0.05) and lower erythrocyte deformability (p<0.05) in the diabetic population. CONCLUSION: Macro- and microcirculatory lower limb disorders could be revealed at high prevalence in diabetic patients with retinopathy. Measurement of tcpO 2 and hemorheological variables could be useful to discover patients at higher risk for diabetic foot complications.

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