Longitudinal study of recurrent metastatic melanoma cell lines underscores the individuality of cancer biology

Z. Pós, Tara L. Spivey, Hui Liu, Michele Sommariva, Jinguo Chen, John R. Wunderlich, Giulia Parisi, Sara Tomei, Ben D. Ayotte, David F. Stroncek, Joel A. Malek, Paul F. Robbins, Licia Rivoltini, Michele Maio, Lotfi Chouchane, Ena Wang, Francesco M. Marincola

Research output: Article

Abstract

Recurrent metastatic melanoma provides a unique opportunity to analyze disease evolution in metastatic cancer. Here, we followed up eight patients with an unusually prolonged history of metastatic melanoma, who developed a total of 26 recurrences over several years. Cell lines derived from each metastasis were analyzed by comparative genomic hybridization and global transcript analysis. We observed that conserved, patient-specific characteristics remain stable in recurrent metastatic melanoma even after years and several recurrences. Differences among individual patients exceeded within-patient lesion variability, both at the DNA copy number (P

Original languageEnglish
Pages (from-to)1389-1396
Number of pages8
JournalJournal of Investigative Dermatology
Volume134
Issue number5
DOIs
Publication statusPublished - 2014

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Individuality
Longitudinal Studies
Melanoma
Cells
Cell Line
DNA
Neoplasms
Recurrence
Comparative Genomic Hybridization
Neoplasm Metastasis

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Longitudinal study of recurrent metastatic melanoma cell lines underscores the individuality of cancer biology. / Pós, Z.; Spivey, Tara L.; Liu, Hui; Sommariva, Michele; Chen, Jinguo; Wunderlich, John R.; Parisi, Giulia; Tomei, Sara; Ayotte, Ben D.; Stroncek, David F.; Malek, Joel A.; Robbins, Paul F.; Rivoltini, Licia; Maio, Michele; Chouchane, Lotfi; Wang, Ena; Marincola, Francesco M.

In: Journal of Investigative Dermatology, Vol. 134, No. 5, 2014, p. 1389-1396.

Research output: Article

Pós, Z, Spivey, TL, Liu, H, Sommariva, M, Chen, J, Wunderlich, JR, Parisi, G, Tomei, S, Ayotte, BD, Stroncek, DF, Malek, JA, Robbins, PF, Rivoltini, L, Maio, M, Chouchane, L, Wang, E & Marincola, FM 2014, 'Longitudinal study of recurrent metastatic melanoma cell lines underscores the individuality of cancer biology', Journal of Investigative Dermatology, vol. 134, no. 5, pp. 1389-1396. https://doi.org/10.1038/jid.2013.495
Pós, Z. ; Spivey, Tara L. ; Liu, Hui ; Sommariva, Michele ; Chen, Jinguo ; Wunderlich, John R. ; Parisi, Giulia ; Tomei, Sara ; Ayotte, Ben D. ; Stroncek, David F. ; Malek, Joel A. ; Robbins, Paul F. ; Rivoltini, Licia ; Maio, Michele ; Chouchane, Lotfi ; Wang, Ena ; Marincola, Francesco M. / Longitudinal study of recurrent metastatic melanoma cell lines underscores the individuality of cancer biology. In: Journal of Investigative Dermatology. 2014 ; Vol. 134, No. 5. pp. 1389-1396.
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