Location of glutamatergic/aspartatergic neurons projecting to the hypothalamic ventromedial nucleus studied by autoradiography of retrogradely transported [3H]d-aspartate

Research output: Article

5 Citations (Scopus)

Abstract

The hypothalamic ventromedial nucleus is a prominent cell group, which is involved in the control of feeding, sexual behavior and cardiovascular function as well as having other functions. The nucleus receives inputs from various forebrain structures and has a dense glutamatergic innervation. The aim of the present investigations was to reveal the location of glutamatergic neurons in the telencephalon and diencephalon projecting to this hypothalamic cell group. [3H]d-aspartate retrograde autoradiography was used injecting the tracer into the ventromedial nucleus. We detected radiolabeled neurons in telencephalic structures including the lateral septum, bed nucleus of the stria terminalis and the amygdala, and in various diencephalic regions, such as the medial preoptic area, hypothalamic paraventricular nucleus, periventricular nucleus, anterior hypothalamic area, ventral premamillary nucleus, thalamic paraventricular and parataenial nuclei and in the hypothalamic ventromedial nucleus itself. Our observations are the first data on the location of glutamatergic neurons terminating in the hypothalamic ventromedial nucleus. The findings indicate that glutamatergic innervation of the ventromedial nucleus is very complex.

Original languageEnglish
Pages (from-to)210-224
Number of pages15
JournalNeuroscience
Volume176
DOIs
Publication statusPublished - márc. 10 2011

Fingerprint

Ventromedial Hypothalamic Nucleus
Autoradiography
Aspartic Acid
Telencephalon
Septal Nuclei
Paraventricular Hypothalamic Nucleus
Neurons
Midline Thalamic Nuclei
Anterior Hypothalamic Nucleus
Thalamic Nuclei
Diencephalon
Preoptic Area
Feeding Behavior
Prosencephalon
Amygdala
Sexual Behavior

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{b26046160d844254865cb98c2584db38,
title = "Location of glutamatergic/aspartatergic neurons projecting to the hypothalamic ventromedial nucleus studied by autoradiography of retrogradely transported [3H]d-aspartate",
abstract = "The hypothalamic ventromedial nucleus is a prominent cell group, which is involved in the control of feeding, sexual behavior and cardiovascular function as well as having other functions. The nucleus receives inputs from various forebrain structures and has a dense glutamatergic innervation. The aim of the present investigations was to reveal the location of glutamatergic neurons in the telencephalon and diencephalon projecting to this hypothalamic cell group. [3H]d-aspartate retrograde autoradiography was used injecting the tracer into the ventromedial nucleus. We detected radiolabeled neurons in telencephalic structures including the lateral septum, bed nucleus of the stria terminalis and the amygdala, and in various diencephalic regions, such as the medial preoptic area, hypothalamic paraventricular nucleus, periventricular nucleus, anterior hypothalamic area, ventral premamillary nucleus, thalamic paraventricular and parataenial nuclei and in the hypothalamic ventromedial nucleus itself. Our observations are the first data on the location of glutamatergic neurons terminating in the hypothalamic ventromedial nucleus. The findings indicate that glutamatergic innervation of the ventromedial nucleus is very complex.",
keywords = "Glutamatergic input, Hypothalamus, Rat, Retrograde labeling, Ventromedial nucleus",
author = "J. Kiss and A. Cs{\'a}ki and B. Hal{\'a}sz",
year = "2011",
month = "3",
day = "10",
doi = "10.1016/j.neuroscience.2010.12.047",
language = "English",
volume = "176",
pages = "210--224",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Location of glutamatergic/aspartatergic neurons projecting to the hypothalamic ventromedial nucleus studied by autoradiography of retrogradely transported [3H]d-aspartate

AU - Kiss, J.

AU - Csáki, A.

AU - Halász, B.

PY - 2011/3/10

Y1 - 2011/3/10

N2 - The hypothalamic ventromedial nucleus is a prominent cell group, which is involved in the control of feeding, sexual behavior and cardiovascular function as well as having other functions. The nucleus receives inputs from various forebrain structures and has a dense glutamatergic innervation. The aim of the present investigations was to reveal the location of glutamatergic neurons in the telencephalon and diencephalon projecting to this hypothalamic cell group. [3H]d-aspartate retrograde autoradiography was used injecting the tracer into the ventromedial nucleus. We detected radiolabeled neurons in telencephalic structures including the lateral septum, bed nucleus of the stria terminalis and the amygdala, and in various diencephalic regions, such as the medial preoptic area, hypothalamic paraventricular nucleus, periventricular nucleus, anterior hypothalamic area, ventral premamillary nucleus, thalamic paraventricular and parataenial nuclei and in the hypothalamic ventromedial nucleus itself. Our observations are the first data on the location of glutamatergic neurons terminating in the hypothalamic ventromedial nucleus. The findings indicate that glutamatergic innervation of the ventromedial nucleus is very complex.

AB - The hypothalamic ventromedial nucleus is a prominent cell group, which is involved in the control of feeding, sexual behavior and cardiovascular function as well as having other functions. The nucleus receives inputs from various forebrain structures and has a dense glutamatergic innervation. The aim of the present investigations was to reveal the location of glutamatergic neurons in the telencephalon and diencephalon projecting to this hypothalamic cell group. [3H]d-aspartate retrograde autoradiography was used injecting the tracer into the ventromedial nucleus. We detected radiolabeled neurons in telencephalic structures including the lateral septum, bed nucleus of the stria terminalis and the amygdala, and in various diencephalic regions, such as the medial preoptic area, hypothalamic paraventricular nucleus, periventricular nucleus, anterior hypothalamic area, ventral premamillary nucleus, thalamic paraventricular and parataenial nuclei and in the hypothalamic ventromedial nucleus itself. Our observations are the first data on the location of glutamatergic neurons terminating in the hypothalamic ventromedial nucleus. The findings indicate that glutamatergic innervation of the ventromedial nucleus is very complex.

KW - Glutamatergic input

KW - Hypothalamus

KW - Rat

KW - Retrograde labeling

KW - Ventromedial nucleus

UR - http://www.scopus.com/inward/record.url?scp=79851516881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79851516881&partnerID=8YFLogxK

U2 - 10.1016/j.neuroscience.2010.12.047

DO - 10.1016/j.neuroscience.2010.12.047

M3 - Article

C2 - 21195748

AN - SCOPUS:79851516881

VL - 176

SP - 210

EP - 224

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -