Linkage and association study of FcγR polymorphisms in celiac disease

I. Sareneva, L. L.E. Koskinen, I. R. Korponay-Szabo, K. Kaukinen, K. Kurppa, F. Ziberna, S. Vatta, T. Not, A. Ventura, R. Ádány, Z. Pocsai, G. Széles, M. Mäki, P. Saavalainen, E. Einarsdottir

Research output: Article

5 Citations (Scopus)

Abstract

The Fcγ receptor cluster on chromosome 1q23 contains a number of genes that may affect susceptibility to celiac disease, but previous studies have yielded contradictory results. We studied the FcγRIIa*A519G (rs1801274) and FcγRIIIa*A559C (rs396991) single nucleotide polymorphisms in celiac disease families from Hungary and Finland and in celiac disease case-control materials from Hungary and Italy. Neither the Hungarian nor the Italian case-control material or a meta-analysis of the combined case-control material showed significant single-marker or haplotype association. In addition, neither linkage nor family-based association tests showed evidence for association in the Finnish or Hungarian family material. This study thus does not support a previous publication showing FcγR association with celiac disease.

Original languageEnglish
Pages (from-to)54-58
Number of pages5
JournalTissue Antigens
Volume73
Issue number1
DOIs
Publication statusPublished - jan. 2009

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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    Sareneva, I., Koskinen, L. L. E., Korponay-Szabo, I. R., Kaukinen, K., Kurppa, K., Ziberna, F., Vatta, S., Not, T., Ventura, A., Ádány, R., Pocsai, Z., Széles, G., Mäki, M., Saavalainen, P., & Einarsdottir, E. (2009). Linkage and association study of FcγR polymorphisms in celiac disease. Tissue Antigens, 73(1), 54-58. https://doi.org/10.1111/j.1399-0039.2008.01179.x