Ligand-specific cross-inhibition of monocyte phagocytosis

M. Kavai, M. Sandor, G. Szegedi, J. Gergely

Research output: Article

2 Citations (Scopus)

Abstract

Human monocytes exposed to particles reacting with receptors of one specific type demonstrate a markedly reduced phagocytosis of particles reacting with receptors of another type. The phagocytosis of yeast particles (Saccharomyces cerevisiae) coated with C3 fragments and of uncoated ones by monocytes can inhibit the subsequent endocytosis of sheep erythrocytes sensitized with IgG antibody and vice versa. The erythrocytes were labelled with 51Cr and the yeast particles with 125I. The dependence of the receptor-ligand reaction on temperature and time of preincubation, as well as on ratio of cell and particle, suggests that this cross-inhibition may be associated with plasma membrane modulations beginning with the attachment of ligands to a receptor and followed by their endocytosis. The differences between the functions of temperature, time, and concentration in inhibition caused by different receptor-ligand reactions suggest that these membrane modulations are probably ligand-specific processes.

Original languageEnglish
Pages (from-to)397-402
Number of pages6
JournalScandinavian Journal of Immunology
Volume28
Issue number4
Publication statusPublished - 1988

Fingerprint

Phagocytosis
Monocytes
Ligands
Endocytosis
Yeasts
Erythrocytes
Temperature
Saccharomyces cerevisiae
Sheep
Immunoglobulin G
Cell Membrane
Membranes
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Ligand-specific cross-inhibition of monocyte phagocytosis. / Kavai, M.; Sandor, M.; Szegedi, G.; Gergely, J.

In: Scandinavian Journal of Immunology, Vol. 28, No. 4, 1988, p. 397-402.

Research output: Article

@article{1bd2e5dddb914f8397a052231ab44c69,
title = "Ligand-specific cross-inhibition of monocyte phagocytosis",
abstract = "Human monocytes exposed to particles reacting with receptors of one specific type demonstrate a markedly reduced phagocytosis of particles reacting with receptors of another type. The phagocytosis of yeast particles (Saccharomyces cerevisiae) coated with C3 fragments and of uncoated ones by monocytes can inhibit the subsequent endocytosis of sheep erythrocytes sensitized with IgG antibody and vice versa. The erythrocytes were labelled with 51Cr and the yeast particles with 125I. The dependence of the receptor-ligand reaction on temperature and time of preincubation, as well as on ratio of cell and particle, suggests that this cross-inhibition may be associated with plasma membrane modulations beginning with the attachment of ligands to a receptor and followed by their endocytosis. The differences between the functions of temperature, time, and concentration in inhibition caused by different receptor-ligand reactions suggest that these membrane modulations are probably ligand-specific processes.",
author = "M. Kavai and M. Sandor and G. Szegedi and J. Gergely",
year = "1988",
language = "English",
volume = "28",
pages = "397--402",
journal = "Scandinavian Journal of Immunology",
issn = "0300-9475",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Ligand-specific cross-inhibition of monocyte phagocytosis

AU - Kavai, M.

AU - Sandor, M.

AU - Szegedi, G.

AU - Gergely, J.

PY - 1988

Y1 - 1988

N2 - Human monocytes exposed to particles reacting with receptors of one specific type demonstrate a markedly reduced phagocytosis of particles reacting with receptors of another type. The phagocytosis of yeast particles (Saccharomyces cerevisiae) coated with C3 fragments and of uncoated ones by monocytes can inhibit the subsequent endocytosis of sheep erythrocytes sensitized with IgG antibody and vice versa. The erythrocytes were labelled with 51Cr and the yeast particles with 125I. The dependence of the receptor-ligand reaction on temperature and time of preincubation, as well as on ratio of cell and particle, suggests that this cross-inhibition may be associated with plasma membrane modulations beginning with the attachment of ligands to a receptor and followed by their endocytosis. The differences between the functions of temperature, time, and concentration in inhibition caused by different receptor-ligand reactions suggest that these membrane modulations are probably ligand-specific processes.

AB - Human monocytes exposed to particles reacting with receptors of one specific type demonstrate a markedly reduced phagocytosis of particles reacting with receptors of another type. The phagocytosis of yeast particles (Saccharomyces cerevisiae) coated with C3 fragments and of uncoated ones by monocytes can inhibit the subsequent endocytosis of sheep erythrocytes sensitized with IgG antibody and vice versa. The erythrocytes were labelled with 51Cr and the yeast particles with 125I. The dependence of the receptor-ligand reaction on temperature and time of preincubation, as well as on ratio of cell and particle, suggests that this cross-inhibition may be associated with plasma membrane modulations beginning with the attachment of ligands to a receptor and followed by their endocytosis. The differences between the functions of temperature, time, and concentration in inhibition caused by different receptor-ligand reactions suggest that these membrane modulations are probably ligand-specific processes.

UR - http://www.scopus.com/inward/record.url?scp=0024263720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024263720&partnerID=8YFLogxK

M3 - Article

C2 - 2848312

AN - SCOPUS:0024263720

VL - 28

SP - 397

EP - 402

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

SN - 0300-9475

IS - 4

ER -