Late cardiovascular events after allogeneic hematopoietic stem cell transplantation: A retrospective multicenter study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation

André Tichelli, Jakob Passweg, Dorota Wójcik, Alicia Rovó, Jean Luc Harousseau, T. Masszi, Axel Zander, Albert Békássy, Charles Crawley, Mutlu Arat, Simona Sica, Patrick Lutz, Gérard Socié

Research output: Article

106 Citations (Scopus)

Abstract

Background: Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. Design and Methods: This is a retrospective mutlicenter European Group of Blood and Marrow Transplantation (EBMT) analysis, including 548 long-term survivors treated in ten EBMT transplant centers, who underwent hematopoietic stem cell transplantation between 1990 and 1995 and survived ≥1 year after the transplant. All arterial events occurring after hematopoietic stem cell transplantation (cerebral, coronary, peripheral) were reported. Results: Twenty (3.6%) out of 548 patients had a cardiovascular event in at least one arterial territory. The median age at occurence of cardiovascular events was 54 years (range, 41-70). The cumulative incidence of a first arterial event 15 years after hematopoietic stem cell transplantation was 6% (95% CI, 3%-10%). The cumulative incidence for patients with a high global cardiovascular risk score, defined as having ≥50% of the risk factors (arterial hypertension, diabetes, dyslipidemia, increased body-mass index, physical inactivity, smoking) was 17%, as compared to 4% in those with a low risk score. In multivariate analysis age older than 30 years at last follow-up, and a high global cardiovascular risk score were associated with, respectively, 6.4-fold and 9.8-fold increases in the risk of an arterial event. Conclusions: Long-term survivors after allogeneic hematopoietic stem cell transplantation are likely to have an increased risk of premature cardiovascular accidents.

Original languageEnglish
Pages (from-to)1203-1210
Number of pages8
JournalHaematologica
Volume93
Issue number8
DOIs
Publication statusPublished - aug. 2008

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Hematopoietic Stem Cell Transplantation
Multicenter Studies
Retrospective Studies
Blood Group Antigens
Transplants
Survivors
Incidence
Transplantation
Bone Marrow
Dyslipidemias
Accidents
Body Mass Index
Multivariate Analysis
Smoking
Hypertension

ASJC Scopus subject areas

  • Hematology

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Late cardiovascular events after allogeneic hematopoietic stem cell transplantation : A retrospective multicenter study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation. / Tichelli, André; Passweg, Jakob; Wójcik, Dorota; Rovó, Alicia; Harousseau, Jean Luc; Masszi, T.; Zander, Axel; Békássy, Albert; Crawley, Charles; Arat, Mutlu; Sica, Simona; Lutz, Patrick; Socié, Gérard.

In: Haematologica, Vol. 93, No. 8, 08.2008, p. 1203-1210.

Research output: Article

Tichelli, André ; Passweg, Jakob ; Wójcik, Dorota ; Rovó, Alicia ; Harousseau, Jean Luc ; Masszi, T. ; Zander, Axel ; Békássy, Albert ; Crawley, Charles ; Arat, Mutlu ; Sica, Simona ; Lutz, Patrick ; Socié, Gérard. / Late cardiovascular events after allogeneic hematopoietic stem cell transplantation : A retrospective multicenter study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation. In: Haematologica. 2008 ; Vol. 93, No. 8. pp. 1203-1210.
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abstract = "Background: Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. Design and Methods: This is a retrospective mutlicenter European Group of Blood and Marrow Transplantation (EBMT) analysis, including 548 long-term survivors treated in ten EBMT transplant centers, who underwent hematopoietic stem cell transplantation between 1990 and 1995 and survived ≥1 year after the transplant. All arterial events occurring after hematopoietic stem cell transplantation (cerebral, coronary, peripheral) were reported. Results: Twenty (3.6{\%}) out of 548 patients had a cardiovascular event in at least one arterial territory. The median age at occurence of cardiovascular events was 54 years (range, 41-70). The cumulative incidence of a first arterial event 15 years after hematopoietic stem cell transplantation was 6{\%} (95{\%} CI, 3{\%}-10{\%}). The cumulative incidence for patients with a high global cardiovascular risk score, defined as having ≥50{\%} of the risk factors (arterial hypertension, diabetes, dyslipidemia, increased body-mass index, physical inactivity, smoking) was 17{\%}, as compared to 4{\%} in those with a low risk score. In multivariate analysis age older than 30 years at last follow-up, and a high global cardiovascular risk score were associated with, respectively, 6.4-fold and 9.8-fold increases in the risk of an arterial event. Conclusions: Long-term survivors after allogeneic hematopoietic stem cell transplantation are likely to have an increased risk of premature cardiovascular accidents.",
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TY - JOUR

T1 - Late cardiovascular events after allogeneic hematopoietic stem cell transplantation

T2 - A retrospective multicenter study of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation

AU - Tichelli, André

AU - Passweg, Jakob

AU - Wójcik, Dorota

AU - Rovó, Alicia

AU - Harousseau, Jean Luc

AU - Masszi, T.

AU - Zander, Axel

AU - Békássy, Albert

AU - Crawley, Charles

AU - Arat, Mutlu

AU - Sica, Simona

AU - Lutz, Patrick

AU - Socié, Gérard

PY - 2008/8

Y1 - 2008/8

N2 - Background: Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. Design and Methods: This is a retrospective mutlicenter European Group of Blood and Marrow Transplantation (EBMT) analysis, including 548 long-term survivors treated in ten EBMT transplant centers, who underwent hematopoietic stem cell transplantation between 1990 and 1995 and survived ≥1 year after the transplant. All arterial events occurring after hematopoietic stem cell transplantation (cerebral, coronary, peripheral) were reported. Results: Twenty (3.6%) out of 548 patients had a cardiovascular event in at least one arterial territory. The median age at occurence of cardiovascular events was 54 years (range, 41-70). The cumulative incidence of a first arterial event 15 years after hematopoietic stem cell transplantation was 6% (95% CI, 3%-10%). The cumulative incidence for patients with a high global cardiovascular risk score, defined as having ≥50% of the risk factors (arterial hypertension, diabetes, dyslipidemia, increased body-mass index, physical inactivity, smoking) was 17%, as compared to 4% in those with a low risk score. In multivariate analysis age older than 30 years at last follow-up, and a high global cardiovascular risk score were associated with, respectively, 6.4-fold and 9.8-fold increases in the risk of an arterial event. Conclusions: Long-term survivors after allogeneic hematopoietic stem cell transplantation are likely to have an increased risk of premature cardiovascular accidents.

AB - Background: Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. Design and Methods: This is a retrospective mutlicenter European Group of Blood and Marrow Transplantation (EBMT) analysis, including 548 long-term survivors treated in ten EBMT transplant centers, who underwent hematopoietic stem cell transplantation between 1990 and 1995 and survived ≥1 year after the transplant. All arterial events occurring after hematopoietic stem cell transplantation (cerebral, coronary, peripheral) were reported. Results: Twenty (3.6%) out of 548 patients had a cardiovascular event in at least one arterial territory. The median age at occurence of cardiovascular events was 54 years (range, 41-70). The cumulative incidence of a first arterial event 15 years after hematopoietic stem cell transplantation was 6% (95% CI, 3%-10%). The cumulative incidence for patients with a high global cardiovascular risk score, defined as having ≥50% of the risk factors (arterial hypertension, diabetes, dyslipidemia, increased body-mass index, physical inactivity, smoking) was 17%, as compared to 4% in those with a low risk score. In multivariate analysis age older than 30 years at last follow-up, and a high global cardiovascular risk score were associated with, respectively, 6.4-fold and 9.8-fold increases in the risk of an arterial event. Conclusions: Long-term survivors after allogeneic hematopoietic stem cell transplantation are likely to have an increased risk of premature cardiovascular accidents.

KW - Cardiovascular

KW - Late effects

KW - Long-term survivors

KW - Stem cell transplantation

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U2 - 10.3324/haematol.12949

DO - 10.3324/haematol.12949

M3 - Article

C2 - 18556401

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VL - 93

SP - 1203

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JO - Haematologica

JF - Haematologica

SN - 0390-6078

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