Lack of squalene and lanosterol synthesis by the perfused human placenta at term

H. A. Van Leusden, Ch Thomas, G. Telegdy, E. Diczfalusy

Research output: Article

3 Citations (Scopus)

Abstract

Three human term placentas were perfused in vitro with 1.6-2.4 mCi of carbon-14 labelled sodium acetate for 90-120 min and attempts were made to isolate from the placentas and perfusates labelled squalene, lanosterol, cholesterol, pregnenolone and progesterone. All carbon-14 labelled material was dissociated from the squatene, cholesterol, pregnenolone and progesterone isolated from the three placentas and three perfusates. The same was found with regard to lanosterol isolated from three perfusates and one placenta. Minute amounts of radiochemically homogeneous lanosterol were isolated from the second placenta, whereas the evidence was inconclusive in the case of minute amounts of lanosterol-like material recovered from the third placenta. It is concluded that little, if any, squalene, lanosterol and cholesterol are synthesized by the human placenta perfused at term.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalJournal of Steroid Biochemistry
Volume4
Issue number4
DOIs
Publication statusPublished - 1973

Fingerprint

Lanosterol
Squalene
Placenta
Pregnenolone
Cholesterol
Progesterone
Carbon
Sodium Acetate

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Lack of squalene and lanosterol synthesis by the perfused human placenta at term. / Van Leusden, H. A.; Thomas, Ch; Telegdy, G.; Diczfalusy, E.

In: Journal of Steroid Biochemistry, Vol. 4, No. 4, 1973, p. 349-354.

Research output: Article

Van Leusden, H. A. ; Thomas, Ch ; Telegdy, G. ; Diczfalusy, E. / Lack of squalene and lanosterol synthesis by the perfused human placenta at term. In: Journal of Steroid Biochemistry. 1973 ; Vol. 4, No. 4. pp. 349-354.
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