K+ channels and T-cell synapses: The molecular background for efficient immunomodulation is shaping up

Research output: Short survey

24 Citations (Scopus)

Abstract

Diverse K+ channels exhibit differential expression and function in human lymphocytes. Voltage-gated and Ca2+-activated K+ channels have a significant impact on both T-cell activation and the overall immune response. A recent study on the plasma membrane organization of Kv1.3 K+ channels in human T cells provides new insights into the immunoregulatory functions of K+ channels, which might result in new and improved immune suppression protocols targeted to ion channels and/or T-cell signaling and accessory molecules.

Original languageEnglish
Pages (from-to)385-389
Number of pages5
JournalTrends in Pharmacological Sciences
Volume24
Issue number8
DOIs
Publication statusPublished - aug. 1 2003

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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