Kinetic investigation of the Pd/carbon-(S)-proline system in reduction of isophorone and acetophenone and comparison with known enantioselective hydrogenations were camed out. An addition reaction of (S)-proline with the substrates, and the selective hydrogenation of this adduct results in the optically active products, the kinetic analysis verified this mode of action: these are rather diastereoselective reactions.
ASJC Scopus subject areas
- Condensed Matter Physics
- Physical and Theoretical Chemistry
- Surfaces, Coatings and Films
- Materials Chemistry