Limited tryptic hydrolysis of bovine and ovine pituitary growth hormones has been investigated. From both hormones, a peptide fragment consisting of 38 amino acid residues corresponding to residue positions 96-133 in the structure has been isolated and characterized. It possesses measurable activity in the tibia test for growth-promoting activity. Another peptide fragment derived from the COOH-terminal portion (residues 151-191) of bovine growth hormone has also been isolated and characterized. It too gives measurable response in the tibia test.
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