Is there any difference between the health risk from consumption of recorded and unrecorded spirits containing alcohols other than ethanol? A population-based comparative risk assessment

Orsolya Bujdosó, László Pál, Attila Nagy, Ervin Árnyas, R. Ádány, J. Sándor, Martin McKee, Sándor Szűcs

Research output: Article

2 Citations (Scopus)

Abstract

Alcohol-attributable mortality in certain countries of Central and Eastern Europe (CEE)remains higher than in their western neighbours. The effect of unrecorded alcohol consumption, including home-made fruit spirits have been suggested as an explanation. Besides ethanol, recorded and unrecorded spirits frequently contain other aliphatic alcohols (OAAs). Our aim was to ascertain whether there is any difference in the amounts of OAAs in recorded and unrecorded spirits, and thus the health risk associated with their consumption. The concentrations of ethanol and OAAs in recorded (n = 119)and unrecorded (n = 87)spirits were determined by gas chromatography and used in a Monte Carlo type probabilistic simulation to assess the risk based on average consumption level, consumption by regular drinkers and chronic heavy drinkers. The concentrations of OAAs in unrecorded spirits were significantly higher [median: 9896.1 mg/L, interquartile range (IQR): 7898.3–12 634.6 mg/L]than those in their recorded (median: 975.6 mg/L, IQR: 136.9–4006.7 mg/L)counterparts. Besides ethanol, methanol also posed a health risk at each consumption level. The risk associated with exposure to OAAs was higher only in chronic heavy drinkers consuming unrecorded spirits. These findings reinforce the importance of action to address the risks associated with consumption of recorded and unrecorded spirits.

Original languageEnglish
Pages (from-to)334-345
Number of pages12
JournalRegulatory Toxicology and Pharmacology
Volume106
DOIs
Publication statusPublished - aug. 1 2019

Fingerprint

Health risks
Risk assessment
Ethanol
Alcohols
Health
Population
Eastern Europe
Alcohol Drinking
Gas Chromatography
Methanol
Fruits
Fruit
Gas chromatography
Mortality

ASJC Scopus subject areas

  • Toxicology

Cite this

@article{0b96d11c590a41a98128caa07f454a3d,
title = "Is there any difference between the health risk from consumption of recorded and unrecorded spirits containing alcohols other than ethanol? A population-based comparative risk assessment",
abstract = "Alcohol-attributable mortality in certain countries of Central and Eastern Europe (CEE)remains higher than in their western neighbours. The effect of unrecorded alcohol consumption, including home-made fruit spirits have been suggested as an explanation. Besides ethanol, recorded and unrecorded spirits frequently contain other aliphatic alcohols (OAAs). Our aim was to ascertain whether there is any difference in the amounts of OAAs in recorded and unrecorded spirits, and thus the health risk associated with their consumption. The concentrations of ethanol and OAAs in recorded (n = 119)and unrecorded (n = 87)spirits were determined by gas chromatography and used in a Monte Carlo type probabilistic simulation to assess the risk based on average consumption level, consumption by regular drinkers and chronic heavy drinkers. The concentrations of OAAs in unrecorded spirits were significantly higher [median: 9896.1 mg/L, interquartile range (IQR): 7898.3–12 634.6 mg/L]than those in their recorded (median: 975.6 mg/L, IQR: 136.9–4006.7 mg/L)counterparts. Besides ethanol, methanol also posed a health risk at each consumption level. The risk associated with exposure to OAAs was higher only in chronic heavy drinkers consuming unrecorded spirits. These findings reinforce the importance of action to address the risks associated with consumption of recorded and unrecorded spirits.",
keywords = "Alcohol consumption, Higher alcohols, Margin of exposure risk assessment, Recorded spirits, Unrecorded spirits",
author = "Orsolya Bujdos{\'o} and L{\'a}szl{\'o} P{\'a}l and Attila Nagy and Ervin {\'A}rnyas and R. {\'A}d{\'a}ny and J. S{\'a}ndor and Martin McKee and S{\'a}ndor Szűcs",
year = "2019",
month = "8",
day = "1",
doi = "10.1016/j.yrtph.2019.05.020",
language = "English",
volume = "106",
pages = "334--345",
journal = "Regulatory Toxicology and Pharmacology",
issn = "0273-2300",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Is there any difference between the health risk from consumption of recorded and unrecorded spirits containing alcohols other than ethanol? A population-based comparative risk assessment

AU - Bujdosó, Orsolya

AU - Pál, László

AU - Nagy, Attila

AU - Árnyas, Ervin

AU - Ádány, R.

AU - Sándor, J.

AU - McKee, Martin

AU - Szűcs, Sándor

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Alcohol-attributable mortality in certain countries of Central and Eastern Europe (CEE)remains higher than in their western neighbours. The effect of unrecorded alcohol consumption, including home-made fruit spirits have been suggested as an explanation. Besides ethanol, recorded and unrecorded spirits frequently contain other aliphatic alcohols (OAAs). Our aim was to ascertain whether there is any difference in the amounts of OAAs in recorded and unrecorded spirits, and thus the health risk associated with their consumption. The concentrations of ethanol and OAAs in recorded (n = 119)and unrecorded (n = 87)spirits were determined by gas chromatography and used in a Monte Carlo type probabilistic simulation to assess the risk based on average consumption level, consumption by regular drinkers and chronic heavy drinkers. The concentrations of OAAs in unrecorded spirits were significantly higher [median: 9896.1 mg/L, interquartile range (IQR): 7898.3–12 634.6 mg/L]than those in their recorded (median: 975.6 mg/L, IQR: 136.9–4006.7 mg/L)counterparts. Besides ethanol, methanol also posed a health risk at each consumption level. The risk associated with exposure to OAAs was higher only in chronic heavy drinkers consuming unrecorded spirits. These findings reinforce the importance of action to address the risks associated with consumption of recorded and unrecorded spirits.

AB - Alcohol-attributable mortality in certain countries of Central and Eastern Europe (CEE)remains higher than in their western neighbours. The effect of unrecorded alcohol consumption, including home-made fruit spirits have been suggested as an explanation. Besides ethanol, recorded and unrecorded spirits frequently contain other aliphatic alcohols (OAAs). Our aim was to ascertain whether there is any difference in the amounts of OAAs in recorded and unrecorded spirits, and thus the health risk associated with their consumption. The concentrations of ethanol and OAAs in recorded (n = 119)and unrecorded (n = 87)spirits were determined by gas chromatography and used in a Monte Carlo type probabilistic simulation to assess the risk based on average consumption level, consumption by regular drinkers and chronic heavy drinkers. The concentrations of OAAs in unrecorded spirits were significantly higher [median: 9896.1 mg/L, interquartile range (IQR): 7898.3–12 634.6 mg/L]than those in their recorded (median: 975.6 mg/L, IQR: 136.9–4006.7 mg/L)counterparts. Besides ethanol, methanol also posed a health risk at each consumption level. The risk associated with exposure to OAAs was higher only in chronic heavy drinkers consuming unrecorded spirits. These findings reinforce the importance of action to address the risks associated with consumption of recorded and unrecorded spirits.

KW - Alcohol consumption

KW - Higher alcohols

KW - Margin of exposure risk assessment

KW - Recorded spirits

KW - Unrecorded spirits

UR - http://www.scopus.com/inward/record.url?scp=85066241213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066241213&partnerID=8YFLogxK

U2 - 10.1016/j.yrtph.2019.05.020

DO - 10.1016/j.yrtph.2019.05.020

M3 - Article

AN - SCOPUS:85066241213

VL - 106

SP - 334

EP - 345

JO - Regulatory Toxicology and Pharmacology

JF - Regulatory Toxicology and Pharmacology

SN - 0273-2300

ER -