Is aging a barrier to reprogramming? Lessons from induced pluripotent stem cells

Phetcharat Phanthong, Hadas Raveh-Amit, Tong Li, Yindee Kitiyanant, A. Dinnyés

Research output: Article

11 Citations (Scopus)

Abstract

The discovery of induced pluripotent stem cells (iPSCs) has the potential to revolutionize the field of regenerative medicine. In the past few years, iPSCs have been the subject of intensive research towards their application in disease modeling and drug screening. In the future, these cells may be applied in cell therapy to replace or regenerate tissues by autologous transplantation. However, two major hurdles need to be resolved in order to reach the later goal: the low reprogramming efficiency and the safety risks, such as the integration of foreign DNA into the genome of the cells and the tumor formation potential arising from transplantation of residual undifferentiated cells. Recently, aging emerged as one of the barriers that accounts, at least in part, for the low reprogramming efficiency of bona fide iPSCs. Here, we review the molecular pathways linking aging and reprogramming along with the unanswered questions in the field. We discuss whether reprogramming rejuvenates the molecular and cellular features associated with age, and present the recent advances with iPSC-based models, contributing to our understanding of physiological and premature aging.

Original languageEnglish
Pages (from-to)591-602
Number of pages12
JournalBiogerontology
Volume14
Issue number6
DOIs
Publication statusPublished - dec. 2013

Fingerprint

Induced Pluripotent Stem Cells
Premature Aging
Tissue Transplantation
Preclinical Drug Evaluations
Regenerative Medicine
Autologous Transplantation
Cell- and Tissue-Based Therapy
Transplantation
Genome
Safety
DNA
Research
Neoplasms

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology
  • Ageing

Cite this

Is aging a barrier to reprogramming? Lessons from induced pluripotent stem cells. / Phanthong, Phetcharat; Raveh-Amit, Hadas; Li, Tong; Kitiyanant, Yindee; Dinnyés, A.

In: Biogerontology, Vol. 14, No. 6, 12.2013, p. 591-602.

Research output: Article

Phanthong, Phetcharat ; Raveh-Amit, Hadas ; Li, Tong ; Kitiyanant, Yindee ; Dinnyés, A. / Is aging a barrier to reprogramming? Lessons from induced pluripotent stem cells. In: Biogerontology. 2013 ; Vol. 14, No. 6. pp. 591-602.
@article{7007250841a04cfbacaafa00b8a5e1bb,
title = "Is aging a barrier to reprogramming? Lessons from induced pluripotent stem cells",
abstract = "The discovery of induced pluripotent stem cells (iPSCs) has the potential to revolutionize the field of regenerative medicine. In the past few years, iPSCs have been the subject of intensive research towards their application in disease modeling and drug screening. In the future, these cells may be applied in cell therapy to replace or regenerate tissues by autologous transplantation. However, two major hurdles need to be resolved in order to reach the later goal: the low reprogramming efficiency and the safety risks, such as the integration of foreign DNA into the genome of the cells and the tumor formation potential arising from transplantation of residual undifferentiated cells. Recently, aging emerged as one of the barriers that accounts, at least in part, for the low reprogramming efficiency of bona fide iPSCs. Here, we review the molecular pathways linking aging and reprogramming along with the unanswered questions in the field. We discuss whether reprogramming rejuvenates the molecular and cellular features associated with age, and present the recent advances with iPSC-based models, contributing to our understanding of physiological and premature aging.",
keywords = "Aging, Cellular senescence, Induced pluripotent stem cells, Nuclear reprogramming, Premature aging",
author = "Phetcharat Phanthong and Hadas Raveh-Amit and Tong Li and Yindee Kitiyanant and A. Dinny{\'e}s",
year = "2013",
month = "12",
doi = "10.1007/s10522-013-9455-2",
language = "English",
volume = "14",
pages = "591--602",
journal = "Biogerontology",
issn = "1389-5729",
publisher = "Springer Netherlands",
number = "6",

}

TY - JOUR

T1 - Is aging a barrier to reprogramming? Lessons from induced pluripotent stem cells

AU - Phanthong, Phetcharat

AU - Raveh-Amit, Hadas

AU - Li, Tong

AU - Kitiyanant, Yindee

AU - Dinnyés, A.

PY - 2013/12

Y1 - 2013/12

N2 - The discovery of induced pluripotent stem cells (iPSCs) has the potential to revolutionize the field of regenerative medicine. In the past few years, iPSCs have been the subject of intensive research towards their application in disease modeling and drug screening. In the future, these cells may be applied in cell therapy to replace or regenerate tissues by autologous transplantation. However, two major hurdles need to be resolved in order to reach the later goal: the low reprogramming efficiency and the safety risks, such as the integration of foreign DNA into the genome of the cells and the tumor formation potential arising from transplantation of residual undifferentiated cells. Recently, aging emerged as one of the barriers that accounts, at least in part, for the low reprogramming efficiency of bona fide iPSCs. Here, we review the molecular pathways linking aging and reprogramming along with the unanswered questions in the field. We discuss whether reprogramming rejuvenates the molecular and cellular features associated with age, and present the recent advances with iPSC-based models, contributing to our understanding of physiological and premature aging.

AB - The discovery of induced pluripotent stem cells (iPSCs) has the potential to revolutionize the field of regenerative medicine. In the past few years, iPSCs have been the subject of intensive research towards their application in disease modeling and drug screening. In the future, these cells may be applied in cell therapy to replace or regenerate tissues by autologous transplantation. However, two major hurdles need to be resolved in order to reach the later goal: the low reprogramming efficiency and the safety risks, such as the integration of foreign DNA into the genome of the cells and the tumor formation potential arising from transplantation of residual undifferentiated cells. Recently, aging emerged as one of the barriers that accounts, at least in part, for the low reprogramming efficiency of bona fide iPSCs. Here, we review the molecular pathways linking aging and reprogramming along with the unanswered questions in the field. We discuss whether reprogramming rejuvenates the molecular and cellular features associated with age, and present the recent advances with iPSC-based models, contributing to our understanding of physiological and premature aging.

KW - Aging

KW - Cellular senescence

KW - Induced pluripotent stem cells

KW - Nuclear reprogramming

KW - Premature aging

UR - http://www.scopus.com/inward/record.url?scp=84890565890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890565890&partnerID=8YFLogxK

U2 - 10.1007/s10522-013-9455-2

DO - 10.1007/s10522-013-9455-2

M3 - Article

C2 - 23963527

AN - SCOPUS:84890565890

VL - 14

SP - 591

EP - 602

JO - Biogerontology

JF - Biogerontology

SN - 1389-5729

IS - 6

ER -