Involvement of central KATP channels in the gastric antisecretory action of α2-adrenoceptor agonists and β-endorphin in rats

Katalin Müllner, András Z. Rónai, Katalin Fülöp, Susanna Fürst, Klára Gyires

Research output: Article

16 Citations (Scopus)

Abstract

The intracerebroventricularly (i.c.v.) injected presynaptic α2-adrenoceptor agonists, clonidine and oxymetazoline, exerted a dose-dependent inhibition on the gastric acid secretion in pylorus-ligated rats; the ED50 values were 20 and 7.5 nmol/rat, respectively. Moreover, β-endorphin, given i.c.v., also decreased acid secretion (ED50 = 0.25 nmol/rat i.c.v.). The antisecretory effect of these compounds was highly reduced by glibenclamide (10 nmol/rat i.c.v.), a selective blocker of KATP channels. These results suggest that KATP channels in the central nervous system are likely to be involved in the centrally initiated antisecretory action of both α2-adrenoceptor agonists and β-endorphin.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalEuropean Journal of Pharmacology
Volume435
Issue number2-3
DOIs
Publication statusPublished - jan. 25 2002

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ASJC Scopus subject areas

  • Pharmacology

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