Investigation of the microprecipitation of folic acid from slightly acidic injection solutions using dynamic light scattering

Sándor Kéki, Tamás Sipos, György Deák, Gêza Mezey, Miklós Zsuga

Research output: Article


Microprecipitation of folic acid was monitored by the dynamic light scattering (DLS) method. The pH was changed by CO2 absorption and addition of HCl. The folic acid solutions were examined over the pH range 8.5 - 4.0. Over the pH range 5.4 - 6.0, microprecipitation was observed and at pH ≤5.2 crude precipitation of folic acid occurred. The dependence of the effective diameter on the pH over the pH range 5.4 - 6.0 is also reported.

Original languageEnglish
Pages (from-to)1333-1334
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Issue number8
Publication statusPublished - jan. 1 1998


ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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