HER-2/neu expresszió vizsgálata heredaganatokban

Research output: Article

Abstract

Over 95% of testicular tumors originate from germ cells, and approximately half of them is the non-seminomatous type. Among growth factors and receptors, the epidermal growth factor receptor (HER-2/neu, c-erbB-2) has major relevance. Its overexpres-sion of cancer patient tissue might predict chemoresistance and poor prognosis. The authors studied HER-2/neu overexpression in non-seminomatous germ cell tumors with Hercep Test Kit. Seven (25%) out of 28 primary non-seminomatous germ cell tumors showed HER-2/neu positivity. Three of the 5 choriocarcinoma components of mixed tumours, and 4 of the tumors containing teratomatous components overexpressed HER-2/neu. Among the HER/2-neu positive cases, 3 patients are in complete remission, 3 patients are in partial remission, and one patient died after primary chemotherapy. It can be established that 25% of the non-seminomatous germ cell tumors containing teratomatous components overexpress HER-2/neu protein. Further molecular investigations and clinicopathological studies are necessary to determine the correlation between HER-2/neu overexpression and therapeutical resistance of testicular tumors.

Translated title of the contributionINvestigation of HER-2/neu expression in testicular tumours
Original languageHungarian
Pages (from-to)13-19
Number of pages7
JournalMagyar Urologia
Volume15
Issue number1
Publication statusPublished - dec. 1 2003

Keywords

  • Chemoresistance
  • HER-2/neu
  • Immunohistochemistry
  • Testicular tumour

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'HER-2/neu expresszió vizsgálata heredaganatokban'. Together they form a unique fingerprint.

  • Cite this