Over 95% of testicular tumors originate from germ cells, and approximately half of them is the non-seminomatous type. Among growth factors and receptors, the epidermal growth factor receptor (HER-2/neu, c-erbB-2) has major relevance. Its overexpres-sion of cancer patient tissue might predict chemoresistance and poor prognosis. The authors studied HER-2/neu overexpression in non-seminomatous germ cell tumors with Hercep Test Kit. Seven (25%) out of 28 primary non-seminomatous germ cell tumors showed HER-2/neu positivity. Three of the 5 choriocarcinoma components of mixed tumours, and 4 of the tumors containing teratomatous components overexpressed HER-2/neu. Among the HER/2-neu positive cases, 3 patients are in complete remission, 3 patients are in partial remission, and one patient died after primary chemotherapy. It can be established that 25% of the non-seminomatous germ cell tumors containing teratomatous components overexpress HER-2/neu protein. Further molecular investigations and clinicopathological studies are necessary to determine the correlation between HER-2/neu overexpression and therapeutical resistance of testicular tumors.
|Translated title of the contribution||INvestigation of HER-2/neu expression in testicular tumours|
|Number of pages||7|
|Publication status||Published - dec. 1 2003|
- Testicular tumour
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