There is a complex network of interacting molecules and systems that contribute to successful implantation and gestation. To provide a suitable microenvironment for the implanting embryo and the developing fetus, a coordinate action of the precizely tuned cytokine balance, appropritae function of decidual NK cells, controlled trophoblast invasion and an appropriate coordination of the neuroendocrine and immune systems are needed. However, there are still ample open questions, e.g., which are the signals that allow certain embryos, but not others- to implant in an otherwise receptive endometrium? What is the origin of decidual NK cells? How do embryo-derive signals affect their function? Recently a European network of laboratories - named EMBIC - sponsored by the European Union, undertook to investigate these problems. Some aspects will be presented in this issue.
ASJC Scopus subject areas
- Endocrine and Autonomic Systems