Interleukin 6 levels in synovial fluids of patients with different arthritides: Correlation with local IgM rheumatoid factor and systemic acute phase protein production

M. Brozik, I. Rosztoczy, K. Meretey, G. Balint, M. Gaal, Z. Balogh, M. Bart, M. Mituszova, V. Velics, A. Falus

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Interleukin 6 (IL-6), a multifunctional cytokine particularly active in regulation of the acute phase response, governs the terminal maturation of B lymphocytes and participates in early activation of T cells. IL-6 levels of synovial fluids of 153 patients with different arthritides were measured by a simple sandwich enzyme immunoassay. Highest IL-6 concentrations were detected in patients with rheumatoid arthritis (RA), particularly in those characterized by very active general symptoms and severe joint pain. High IL-6 levels were detected in patients with juvenile RA with polyarticular onset of disease and in gout. Corresponding to the suggested in vivo relevance of IL-6, dose correlation of IL-6 levels with the synovial IgM rheumatoid factor accumulation was demonstrated. The rate of the correlation between synovial IL-6 level and concentration of serum C-reactive protein in RA was inversely proportional to the dose of steroid treatment in patients with RA.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalJournal of Rheumatology
Issue number1
Publication statusPublished - jan. 1 1992


ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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