Interferon production by cultured human trophoblast induced with double stranded polyribonucleotide

F. Tóth, C. Juhl, N. Nørskov-Lauritsen, P. Mosborg Petersen, P. Ebbesen

Research output: Article

35 Citations (Scopus)

Abstract

Human trophoblast cultures were established from term placentae. Upon exposure to polyriboinosinic-polyribocytidylic acid (poly(I:C)) the cultures produced interferon. Results of neutralization experiments and indirect immunofluorescence studies indicated that the trophoblast produces beta-interferon. The fusion of trophoblast cells into syncytia was accompanied by a restriction in interferon release after stimulation with poly(I:C). It was also demonstrated that the malignant choriocarcinoma cell line JAR produced less interferon than the non-transformed cyto- or syncytiotrophoblast.

Original languageEnglish
Pages (from-to)217-227
Number of pages11
JournalJournal of Reproductive Immunology
Volume17
Issue number3
DOIs
Publication statusPublished - 1990

Fingerprint

Polyribonucleotides
Trophoblasts
Interferons
Choriocarcinoma
Cell Fusion
Interferon-beta
Giant Cells
Indirect Fluorescent Antibody Technique
Placenta
Cell Line
Acids

ASJC Scopus subject areas

  • Immunology
  • Reproductive Medicine

Cite this

Interferon production by cultured human trophoblast induced with double stranded polyribonucleotide. / Tóth, F.; Juhl, C.; Nørskov-Lauritsen, N.; Mosborg Petersen, P.; Ebbesen, P.

In: Journal of Reproductive Immunology, Vol. 17, No. 3, 1990, p. 217-227.

Research output: Article

Tóth, F. ; Juhl, C. ; Nørskov-Lauritsen, N. ; Mosborg Petersen, P. ; Ebbesen, P. / Interferon production by cultured human trophoblast induced with double stranded polyribonucleotide. In: Journal of Reproductive Immunology. 1990 ; Vol. 17, No. 3. pp. 217-227.
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AU - Ebbesen, P.

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