Interaction of Bordetella bronchiseptica, pasteurella multocida, and fumonisin B1 in the porcine respiratory tract as studied by computed tomography

Roland Pósa, Tamás Donkó, P. Bogner, Melinda Kovács, I. Repa, Tibor Magyar

Research output: Article

13 Citations (Scopus)

Abstract

The interaction of Bordetella bronchiseptica, toxigenic Pasteurella multocida serotype D, and the mycotoxin fumonisin B 1 (FB 1) was studied. On day 0 of the experiment, 28 artificially reared 3-day-old piglets were divided into 4 groups (n = 7 each): a control group (A), a group fed FB 1 toxin (B), a group infected with the 2 pathogens (C), and a group infected with the 2 pathogens and fed FB 1 toxin (D). The B. bronchiseptica infection [with 10 6 colony-forming units (CFU)/mL] was performed on day 4 and the P. multocida infection (with 10 8 CFU/mL) on day 16. From day 16 a Fusarium verticillioides fungal culture (dietary FB 1 toxin content 10 mg/kg) was mixed into the feed of groups B and D. In groups C and D, clinical signs including mild serous nasal discharge, sneezing, panting, and hoarseness appeared from day 4, and then from day 16 some piglets had coughing and dyspnea as well. Computed tomography (CT) performed on day 16 demonstrated lung lesions attributable to colonization by B. bronchiseptica in the infected groups. By day 25 the number of piglets exhibiting lesions had increased, and the lesions appeared as well-circumscribed, focal changes characterized by a strong density increase in the affected areas of the lungs. The gross pathological findings confirmed the results obtained by CT. These results indicate that, when combined with dual infection by B. bronchiseptica and P. multocida, dietary exposure of pigs to FB 1 toxin raises the risk of pneumonia and increases the extent and severity of the pathological changes.

Original languageEnglish
Pages (from-to)176-182
Number of pages7
JournalCanadian Journal of Veterinary Research
Volume75
Issue number3
Publication statusPublished - júl. 2011

Fingerprint

Bordetella bronchiseptica
Pasteurella multocida
fumonisin B1
fumonisins
computed tomography
respiratory system
Respiratory System
Swine
Tomography
toxins
swine
lesions (animal)
piglets
Stem Cells
Bordetella Infections
lungs
Pasteurella Infections
infection
Sneezing
Hoarseness

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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title = "Interaction of Bordetella bronchiseptica, pasteurella multocida, and fumonisin B1 in the porcine respiratory tract as studied by computed tomography",
abstract = "The interaction of Bordetella bronchiseptica, toxigenic Pasteurella multocida serotype D, and the mycotoxin fumonisin B 1 (FB 1) was studied. On day 0 of the experiment, 28 artificially reared 3-day-old piglets were divided into 4 groups (n = 7 each): a control group (A), a group fed FB 1 toxin (B), a group infected with the 2 pathogens (C), and a group infected with the 2 pathogens and fed FB 1 toxin (D). The B. bronchiseptica infection [with 10 6 colony-forming units (CFU)/mL] was performed on day 4 and the P. multocida infection (with 10 8 CFU/mL) on day 16. From day 16 a Fusarium verticillioides fungal culture (dietary FB 1 toxin content 10 mg/kg) was mixed into the feed of groups B and D. In groups C and D, clinical signs including mild serous nasal discharge, sneezing, panting, and hoarseness appeared from day 4, and then from day 16 some piglets had coughing and dyspnea as well. Computed tomography (CT) performed on day 16 demonstrated lung lesions attributable to colonization by B. bronchiseptica in the infected groups. By day 25 the number of piglets exhibiting lesions had increased, and the lesions appeared as well-circumscribed, focal changes characterized by a strong density increase in the affected areas of the lungs. The gross pathological findings confirmed the results obtained by CT. These results indicate that, when combined with dual infection by B. bronchiseptica and P. multocida, dietary exposure of pigs to FB 1 toxin raises the risk of pneumonia and increases the extent and severity of the pathological changes.",
author = "Roland P{\'o}sa and Tam{\'a}s Donk{\'o} and P. Bogner and Melinda Kov{\'a}cs and I. Repa and Tibor Magyar",
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T1 - Interaction of Bordetella bronchiseptica, pasteurella multocida, and fumonisin B1 in the porcine respiratory tract as studied by computed tomography

AU - Pósa, Roland

AU - Donkó, Tamás

AU - Bogner, P.

AU - Kovács, Melinda

AU - Repa, I.

AU - Magyar, Tibor

PY - 2011/7

Y1 - 2011/7

N2 - The interaction of Bordetella bronchiseptica, toxigenic Pasteurella multocida serotype D, and the mycotoxin fumonisin B 1 (FB 1) was studied. On day 0 of the experiment, 28 artificially reared 3-day-old piglets were divided into 4 groups (n = 7 each): a control group (A), a group fed FB 1 toxin (B), a group infected with the 2 pathogens (C), and a group infected with the 2 pathogens and fed FB 1 toxin (D). The B. bronchiseptica infection [with 10 6 colony-forming units (CFU)/mL] was performed on day 4 and the P. multocida infection (with 10 8 CFU/mL) on day 16. From day 16 a Fusarium verticillioides fungal culture (dietary FB 1 toxin content 10 mg/kg) was mixed into the feed of groups B and D. In groups C and D, clinical signs including mild serous nasal discharge, sneezing, panting, and hoarseness appeared from day 4, and then from day 16 some piglets had coughing and dyspnea as well. Computed tomography (CT) performed on day 16 demonstrated lung lesions attributable to colonization by B. bronchiseptica in the infected groups. By day 25 the number of piglets exhibiting lesions had increased, and the lesions appeared as well-circumscribed, focal changes characterized by a strong density increase in the affected areas of the lungs. The gross pathological findings confirmed the results obtained by CT. These results indicate that, when combined with dual infection by B. bronchiseptica and P. multocida, dietary exposure of pigs to FB 1 toxin raises the risk of pneumonia and increases the extent and severity of the pathological changes.

AB - The interaction of Bordetella bronchiseptica, toxigenic Pasteurella multocida serotype D, and the mycotoxin fumonisin B 1 (FB 1) was studied. On day 0 of the experiment, 28 artificially reared 3-day-old piglets were divided into 4 groups (n = 7 each): a control group (A), a group fed FB 1 toxin (B), a group infected with the 2 pathogens (C), and a group infected with the 2 pathogens and fed FB 1 toxin (D). The B. bronchiseptica infection [with 10 6 colony-forming units (CFU)/mL] was performed on day 4 and the P. multocida infection (with 10 8 CFU/mL) on day 16. From day 16 a Fusarium verticillioides fungal culture (dietary FB 1 toxin content 10 mg/kg) was mixed into the feed of groups B and D. In groups C and D, clinical signs including mild serous nasal discharge, sneezing, panting, and hoarseness appeared from day 4, and then from day 16 some piglets had coughing and dyspnea as well. Computed tomography (CT) performed on day 16 demonstrated lung lesions attributable to colonization by B. bronchiseptica in the infected groups. By day 25 the number of piglets exhibiting lesions had increased, and the lesions appeared as well-circumscribed, focal changes characterized by a strong density increase in the affected areas of the lungs. The gross pathological findings confirmed the results obtained by CT. These results indicate that, when combined with dual infection by B. bronchiseptica and P. multocida, dietary exposure of pigs to FB 1 toxin raises the risk of pneumonia and increases the extent and severity of the pathological changes.

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