Interaction between 3,5-diacetyl-1,4-dihydropyridines and ampicillin, and erythromycin on different E. coli strains

Györgyi Gunics, Sándor Farkas, Noboru Motohashi, Anamik Shah, Gaveriya Harsukh, Masami Kawase, J. Molnár

Research output: Article

24 Citations (Scopus)

Abstract

Eleven analogues of nifedipine (NP) showed synergistic interactions with ampicillin (Ap) and erythromycin (Er) on Escherichia coli K12LE140/F'lac. The antibacterial effect of Ap was enhanced by most analogues but compound (G9) and (±)-verapamil (VP) were antagonistic. Two of the 11 compounds (G7, G8) were synergistic with Er and four were additive. With a sensitive clinical isolate of E. coli Gy-1/ApsensErres, compound G1 antagonized the antibacterial effect of Ap and a synergistic effect was found in the combination of Er with G4, G5, G6 or G7. None of the drugs had any effect on a multidrug resistant (MDR) clinical isolate of E. coli Gy-2/ApresErres.

Original languageEnglish
Pages (from-to)227-229
Number of pages3
JournalInternational Journal of Antimicrobial Agents
Volume20
Issue number3
DOIs
Publication statusPublished - szept. 1 2002

Fingerprint

Diacetyl
Erythromycin
Ampicillin
Escherichia coli
Nifedipine
Verapamil
Pharmaceutical Preparations
1,4-dihydropyridine

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Interaction between 3,5-diacetyl-1,4-dihydropyridines and ampicillin, and erythromycin on different E. coli strains. / Gunics, Györgyi; Farkas, Sándor; Motohashi, Noboru; Shah, Anamik; Harsukh, Gaveriya; Kawase, Masami; Molnár, J.

In: International Journal of Antimicrobial Agents, Vol. 20, No. 3, 01.09.2002, p. 227-229.

Research output: Article

Gunics, Györgyi ; Farkas, Sándor ; Motohashi, Noboru ; Shah, Anamik ; Harsukh, Gaveriya ; Kawase, Masami ; Molnár, J. / Interaction between 3,5-diacetyl-1,4-dihydropyridines and ampicillin, and erythromycin on different E. coli strains. In: International Journal of Antimicrobial Agents. 2002 ; Vol. 20, No. 3. pp. 227-229.
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AU - Shah, Anamik

AU - Harsukh, Gaveriya

AU - Kawase, Masami

AU - Molnár, J.

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