Inter-ictal network of focal epilepsy and effects of clinical factors on network activity

B. Clemens, Johanna Dömötör, M. Emri, Szilvia Puskás, I. Fekete

Research output: Article

Abstract

Objective: Aim of the study was to explore the inter-ictal, resting-state EEG network in patients with focal epilepsy (FE) and to specify clinical factors that influence network activity. Methods: Functional EEG connectivity (EEGfC) differences were computed between 232 FE patients (FE group) and 77 healthy controls. EEGfC was computed among 23 cortical regions within each hemisphere, for 25 very narrow bands from 1 to 25 Hz. We computed independent effects for six clinical factors on EEGfC in the FE group, by ANOVA and post-hoc t-statistics, corrected for multiple comparisons by false discovery rate method. Results: Robust, statistically significant EEGfC differences emerged between the FE and the healthy control groups. Etiology, seizure type, duration of the illness and antiepileptic treatment were independent factors that influenced EEGfC. Statistically significant results occurred selectively in one or a few very narrow bands and outlined networks. Most abnormal EEGfC findings occurred at frequencies that mediate integrative and motor activities. Conclusions: FE patients have abnormal resting-state EEGfC network activity. Clinical factors significantly modify EEGfC. Significance: Delineation of the FE network and modifying factors can open the way for targeted investigations and introduction of EEGfC into epilepsy research and practice.

Original languageEnglish
Pages (from-to)251-258
Number of pages8
JournalClinical Neurophysiology
Volume130
Issue number2
DOIs
Publication statusPublished - febr. 1 2019

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Partial Epilepsy
Stroke
Electroencephalography
Anticonvulsants
Epilepsy
Analysis of Variance
Seizures
Motor Activity
Control Groups
Research

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Inter-ictal network of focal epilepsy and effects of clinical factors on network activity. / Clemens, B.; Dömötör, Johanna; Emri, M.; Puskás, Szilvia; Fekete, I.

In: Clinical Neurophysiology, Vol. 130, No. 2, 01.02.2019, p. 251-258.

Research output: Article

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