Inhibitory effects of hypertonic saline on P. aeruginosa motility

V. Havasi, Casey O. Hurst, Travis C. Briles, Fan Yang, David G. Bains, Daniel J. Hassett, Eric Sorscher

Research output: Article

20 Citations (Scopus)

Abstract

Salt transport defects in CF lungs predispose to overwhelming and fatal respiratory infection caused by Pseudomonas aeruginosa. Motility of this organism is central to pathogenesis in a number of settings. Incubation of numerous strains of P. aeruginosa with hypertonic saline caused a concentration-dependent decrease in bacterial motility. Reduction of P. aeruginosa virulence through this effect may contribute to clinical efficacy of hypertonic saline aerosols in CF patients.

Original languageEnglish
Pages (from-to)267-269
Number of pages3
JournalJournal of Cystic Fibrosis
Volume7
Issue number4
DOIs
Publication statusPublished - júl. 2008

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Pseudomonas aeruginosa
Aerosols
Respiratory Tract Infections
Virulence
Salts
Lung

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Havasi, V., Hurst, C. O., Briles, T. C., Yang, F., Bains, D. G., Hassett, D. J., & Sorscher, E. (2008). Inhibitory effects of hypertonic saline on P. aeruginosa motility. Journal of Cystic Fibrosis, 7(4), 267-269. https://doi.org/10.1016/j.jcf.2007.11.009

Inhibitory effects of hypertonic saline on P. aeruginosa motility. / Havasi, V.; Hurst, Casey O.; Briles, Travis C.; Yang, Fan; Bains, David G.; Hassett, Daniel J.; Sorscher, Eric.

In: Journal of Cystic Fibrosis, Vol. 7, No. 4, 07.2008, p. 267-269.

Research output: Article

Havasi, V, Hurst, CO, Briles, TC, Yang, F, Bains, DG, Hassett, DJ & Sorscher, E 2008, 'Inhibitory effects of hypertonic saline on P. aeruginosa motility', Journal of Cystic Fibrosis, vol. 7, no. 4, pp. 267-269. https://doi.org/10.1016/j.jcf.2007.11.009
Havasi, V. ; Hurst, Casey O. ; Briles, Travis C. ; Yang, Fan ; Bains, David G. ; Hassett, Daniel J. ; Sorscher, Eric. / Inhibitory effects of hypertonic saline on P. aeruginosa motility. In: Journal of Cystic Fibrosis. 2008 ; Vol. 7, No. 4. pp. 267-269.
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