Inhibition of platelet factor 3 availability by prostacyclin

Hársfalvi, Jolán, L. Muszbek, I. Stadler, L. Fésüs

Research output: Article

3 Citations (Scopus)

Abstract

Preincubation of human platelet rich plasma with PGI2 in a concentration preventing collagen induced platelet aggregation abolished also platelet factor 3 availability brought about by collagen. Following PGI2 pretreatment no second wave aggregation could be elicited by ristocetin. However, primary aggregation as well as platelet factor 3 activity were only partially inhibited in this case and the inhibitory action of PGI2 was not increased by raising its concentration. Similarly, marked but not complete inhibition of platelet factor 3 availability was obtained when kaolin was used as activating agent.

Original languageEnglish
Pages (from-to)935-945
Number of pages11
JournalProstaglandins
Volume20
Issue number5
DOIs
Publication statusPublished - jan. 1 1980

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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