Influence of age on the signal transduction of T cells in mice

Masanori Utsuyama, Zsuzsa Varga, Kiyoko Fukami, Yoshimi Homma, Tadaomi Takenawa, Katsuiku Hirokawa

Research output: Article

55 Citations (Scopus)

Abstract

A 5- to 10-fold decline was observed in the proliferative activity of T cells stimulated with anti- CD3 mAb between young and old mice. However, the number of CD3 molecules on the T cell surface was almost comparable between young and old T cells. The formation of the second messenger such as inositol triphosphate (IP3) and dlacylglycerol (DAG) after mitogenic stimulation decreased in old T cells as compared with young ones. The activity of phospholipase C (PLC), which is responsible for the liberation of IP3 and DAG from phosphatidylinositol-4, 5- blsphosphate (PIP2 was not different between young and old T cells. The content of PIP2 in the membrane was also comparable between young and old T cells. These findings have suggested that the age-related decline in the prollferative activity of T cells could be due to impairment of intracellular signal transduction, probably in the pathway somewhere between TCR and PLC.

Original languageEnglish
Pages (from-to)1177-1182
Number of pages6
JournalInternational Immunology
Volume5
Issue number9
DOIs
Publication statusPublished - szept. 1 1993

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Utsuyama, M., Varga, Z., Fukami, K., Homma, Y., Takenawa, T., & Hirokawa, K. (1993). Influence of age on the signal transduction of T cells in mice. International Immunology, 5(9), 1177-1182. https://doi.org/10.1093/intimm/5.9.1177