Inflammatory reaction as determinant of foreign body reaction is an early and susceptible event after mesh implantation

Holger Gerullis, Evangelos Georgas, M. Borós, Bernd Klosterhalfen, Christoph Eimer, Christian Arndt, Stephan Otto, Dimitri Barski, Dirk Ysebaert, Albert Ramon, Thomas Otto

Research output: Article

15 Citations (Scopus)

Abstract

Purpose. To investigate and relate the ultrashort-term and long-term courses of determinants for foreign body reaction as biocompatibility predictors for meshes in an animal model. Materials and Methods. Three different meshes (TVT, UltraPro, and PVDF) were implanted in sheep. Native and plasma coated meshes were placed bilaterally: (a) interaperitoneally, (b) as fascia onlay, and (c) as muscle onlay (fascia sublay). At 5 min, 20 min, 60 min, and 120 min meshes were explanted and histochemically investigated for inflammatory infiltrate, macrophage infiltration, vessel formation, myofibroblast invasion, and connective tissue accumulation. The results were related to long-term values over 24 months. Results. Macrophage invasion reached highest extents with up to 60% in short-term and decreased within 24 months to about 30%. Inflammatory infiltrate increased within the first 2 hours, the reached levels and the different extents and ranking among the investigated meshes remained stable during long-term follow up. For myofibroblasts, connective tissue, and CD31+ cells, no activity was detected during the first 120 min. Conclusion. The local inflammatory reaction is an early and susceptible event after mesh implantation. It cannot be influenced by prior plasma coating and does not depend on the localisation of implantation.

Original languageEnglish
Article number510807
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

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Foreign-Body Reaction
Inlays
Myofibroblasts
Macrophages
Fascia
Tissue
Connective Tissue Cells
Plasmas
Biocompatibility
Infiltration
Connective Tissue
Muscle
Sheep
Animals
Animal Models
Muscles
Coatings
polyvinylidene fluoride

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Inflammatory reaction as determinant of foreign body reaction is an early and susceptible event after mesh implantation. / Gerullis, Holger; Georgas, Evangelos; Borós, M.; Klosterhalfen, Bernd; Eimer, Christoph; Arndt, Christian; Otto, Stephan; Barski, Dimitri; Ysebaert, Dirk; Ramon, Albert; Otto, Thomas.

In: BioMed Research International, Vol. 2014, 510807, 2014.

Research output: Article

Gerullis, H, Georgas, E, Borós, M, Klosterhalfen, B, Eimer, C, Arndt, C, Otto, S, Barski, D, Ysebaert, D, Ramon, A & Otto, T 2014, 'Inflammatory reaction as determinant of foreign body reaction is an early and susceptible event after mesh implantation', BioMed Research International, vol. 2014, 510807. https://doi.org/10.1155/2014/510807
Gerullis, Holger ; Georgas, Evangelos ; Borós, M. ; Klosterhalfen, Bernd ; Eimer, Christoph ; Arndt, Christian ; Otto, Stephan ; Barski, Dimitri ; Ysebaert, Dirk ; Ramon, Albert ; Otto, Thomas. / Inflammatory reaction as determinant of foreign body reaction is an early and susceptible event after mesh implantation. In: BioMed Research International. 2014 ; Vol. 2014.
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abstract = "Purpose. To investigate and relate the ultrashort-term and long-term courses of determinants for foreign body reaction as biocompatibility predictors for meshes in an animal model. Materials and Methods. Three different meshes (TVT, UltraPro, and PVDF) were implanted in sheep. Native and plasma coated meshes were placed bilaterally: (a) interaperitoneally, (b) as fascia onlay, and (c) as muscle onlay (fascia sublay). At 5 min, 20 min, 60 min, and 120 min meshes were explanted and histochemically investigated for inflammatory infiltrate, macrophage infiltration, vessel formation, myofibroblast invasion, and connective tissue accumulation. The results were related to long-term values over 24 months. Results. Macrophage invasion reached highest extents with up to 60{\%} in short-term and decreased within 24 months to about 30{\%}. Inflammatory infiltrate increased within the first 2 hours, the reached levels and the different extents and ranking among the investigated meshes remained stable during long-term follow up. For myofibroblasts, connective tissue, and CD31+ cells, no activity was detected during the first 120 min. Conclusion. The local inflammatory reaction is an early and susceptible event after mesh implantation. It cannot be influenced by prior plasma coating and does not depend on the localisation of implantation.",
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AU - Gerullis, Holger

AU - Georgas, Evangelos

AU - Borós, M.

AU - Klosterhalfen, Bernd

AU - Eimer, Christoph

AU - Arndt, Christian

AU - Otto, Stephan

AU - Barski, Dimitri

AU - Ysebaert, Dirk

AU - Ramon, Albert

AU - Otto, Thomas

PY - 2014

Y1 - 2014

N2 - Purpose. To investigate and relate the ultrashort-term and long-term courses of determinants for foreign body reaction as biocompatibility predictors for meshes in an animal model. Materials and Methods. Three different meshes (TVT, UltraPro, and PVDF) were implanted in sheep. Native and plasma coated meshes were placed bilaterally: (a) interaperitoneally, (b) as fascia onlay, and (c) as muscle onlay (fascia sublay). At 5 min, 20 min, 60 min, and 120 min meshes were explanted and histochemically investigated for inflammatory infiltrate, macrophage infiltration, vessel formation, myofibroblast invasion, and connective tissue accumulation. The results were related to long-term values over 24 months. Results. Macrophage invasion reached highest extents with up to 60% in short-term and decreased within 24 months to about 30%. Inflammatory infiltrate increased within the first 2 hours, the reached levels and the different extents and ranking among the investigated meshes remained stable during long-term follow up. For myofibroblasts, connective tissue, and CD31+ cells, no activity was detected during the first 120 min. Conclusion. The local inflammatory reaction is an early and susceptible event after mesh implantation. It cannot be influenced by prior plasma coating and does not depend on the localisation of implantation.

AB - Purpose. To investigate and relate the ultrashort-term and long-term courses of determinants for foreign body reaction as biocompatibility predictors for meshes in an animal model. Materials and Methods. Three different meshes (TVT, UltraPro, and PVDF) were implanted in sheep. Native and plasma coated meshes were placed bilaterally: (a) interaperitoneally, (b) as fascia onlay, and (c) as muscle onlay (fascia sublay). At 5 min, 20 min, 60 min, and 120 min meshes were explanted and histochemically investigated for inflammatory infiltrate, macrophage infiltration, vessel formation, myofibroblast invasion, and connective tissue accumulation. The results were related to long-term values over 24 months. Results. Macrophage invasion reached highest extents with up to 60% in short-term and decreased within 24 months to about 30%. Inflammatory infiltrate increased within the first 2 hours, the reached levels and the different extents and ranking among the investigated meshes remained stable during long-term follow up. For myofibroblasts, connective tissue, and CD31+ cells, no activity was detected during the first 120 min. Conclusion. The local inflammatory reaction is an early and susceptible event after mesh implantation. It cannot be influenced by prior plasma coating and does not depend on the localisation of implantation.

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