The objective of our studies was to estimate the association between maternalglomerulonephritis / urinary tract infections (UTI) during pregnancy and structural birthdefects, i.e. congenital abnormalities or adverse pregnancy outcome. The prevalence ofthese maternal diseases during the first trimester of pregnancy in cases with differentcongenital abnormalities was compared to that of matched controls without congenitalabnormalities in the population-based Hungarian Case-Control Surveillance System ofCongenital Abnormalities. Of 22,843 cases with congenital abnormalities, 309 (1.35%)had mothers with glomerulonephritis during pregnancy, compared to 479 (1.26%) of38,151 controls (adjusted POR with 95% CI = 1.0, 0.9-1.2). Specified groups ofcongenital abnormalities were also assessed versus controls. Cases with isolatedintestinal atresia/stenosis (adjusted POR with 95% CI: 6.8, 1.3-37.4) based on five caseswere more likely to have mothers with prospectively and medically recordedglomerulonephritis. A total of 1542 (6.75%) mothers in the case group had UTI duringthe entire pregnancy compared with 2188 (5.74%) mothers in the control group (adjustedprevalence odds ratios [POR] with 95% CI: 1.15, 1.06-1.24). We did not find a higherprevalence of UTI during the second and/or third months of pregnancy in total casegroup (adjusted POR with 95% CI: 1.1, 0.9-1.2) and in any group of CAs including atrialseptal defect type II. In conclusion a higher rate of congenital isolated intestinalatresia/stenosis may be associated with maternal glomerulonephritis. However, thisfinding is considered only as signal and further studies are needed to confirm or rejectthis possible association. Maternal urinary tract infections during pregnancy increase preeclampsiaand polyhydramnios, and in addition the rate of preterm birth; however, thelatter is preventable by appropriate drug treatments. No evidence was found for theteratogenic effect of maternal UTI and related drug treatments during early pregnancy.
|Title of host publication||Infectious Pregnancy Complications|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||28|
|Publication status||Published - márc. 1 2009|
ASJC Scopus subject areas
- Health Professions(all)