Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists

István Borza, Sándor Kolok, Anikó Gere, Éva Ágai-Csongor, B. Ágai, G. Tárkányi, Csilla Horváth, Gizella Barta-Szalai, Éva Bozó, Csilla Kiss, Attila Bielik, József Nagy, Sándor Farkas, György Domány

Research output: Article

31 Citations (Scopus)

Abstract

A novel series of indole-2-carboxamide derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the number and position of OH groups on the indole skeleton as well as the substitution of the piperidine ring on the biological activity of the compounds was studied.

Original languageEnglish
Pages (from-to)3859-3861
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number21
DOIs
Publication statusPublished - nov. 3 2003

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N-Methyl-D-Aspartate Receptors
Bioactivity
Skeleton
Substitution reactions
Derivatives
indole
NR2B NMDA receptor
piperidine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists. / Borza, István; Kolok, Sándor; Gere, Anikó; Ágai-Csongor, Éva; Ágai, B.; Tárkányi, G.; Horváth, Csilla; Barta-Szalai, Gizella; Bozó, Éva; Kiss, Csilla; Bielik, Attila; Nagy, József; Farkas, Sándor; Domány, György.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 21, 03.11.2003, p. 3859-3861.

Research output: Article

Borza, I, Kolok, S, Gere, A, Ágai-Csongor, É, Ágai, B, Tárkányi, G, Horváth, C, Barta-Szalai, G, Bozó, É, Kiss, C, Bielik, A, Nagy, J, Farkas, S & Domány, G 2003, 'Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists', Bioorganic and Medicinal Chemistry Letters, vol. 13, no. 21, pp. 3859-3861. https://doi.org/10.1016/S0960-894X(03)00708-X
Borza, István ; Kolok, Sándor ; Gere, Anikó ; Ágai-Csongor, Éva ; Ágai, B. ; Tárkányi, G. ; Horváth, Csilla ; Barta-Szalai, Gizella ; Bozó, Éva ; Kiss, Csilla ; Bielik, Attila ; Nagy, József ; Farkas, Sándor ; Domány, György. / Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists. In: Bioorganic and Medicinal Chemistry Letters. 2003 ; Vol. 13, No. 21. pp. 3859-3861.
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AU - Ágai, B.

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