Egyedi LORETA-abnormalitások vizsgálata idiopathiás generalizált epilepsziákban

Béla Clemens, Szilvia Puskás, Mónika Besenyei, István Kondákor, Katalin Hollódy, András Fogarasi, Katalin Bense, Miklós Emri, Gábor Opposits, Noémi Zsuzsanna Kovács, István Fekete

Research output: Article

1 Citation (Scopus)

Abstract

Background: Contemporary neuroimaging methods disclosed structural and functional cerebral abnormalities in idiopathic generalized epilepsies (IGEs). However, individual electrical (EEG) abnormalities have not been evaluated yet in IGE patients. Methods: IGE patients were investigated in the drug-free condition and after 3-6 month of antiepileptic treatment. To estimate the reproducibility of qEEG, variables a retrospective recruited cohort of IGE patients was investigated. 19-channel resting state EEG activity was recorded. For each patient a total of 2 minutes EEG activity was analyzed by LORETA (Low Resolution Electromagnetic Tomography). Raw LORETA values were Z-transformed and projected to a MRI template. Z-values outside within the [+3Z] to [-3Z] range were labelled as statistically abnormal. Results: 1. In drug-free condition, 41-50% of IGE patients showed abnormal LORETA values. 2. Abnormal LORETA findings showed great inter-individual variability. 3. Most abnormal LORETA-findings were symmetrical. 4. Most maximum Z-values were localized to frontal or temporal cortex. 5. Succesfull treatment was mostly coupled with disappearence of LORETA-abnormality, persistent seizures were accompanied by persistent LORETA abnormality. Discussion: 1. LORETA abnormalities detected in the untreated condition reflect seizure-generating property of the cortex in IGE patients. 2. Maximum LORETA-Z abnormalities were topographically congruent with structural abnormalities reported by other research groups. 3. LORE-TA might help to investigate drug effects at the whole-brain level.

Translated title of the contributionIndividual evaluation of loreta abnormalities in idiopathic generalized epilepsy
Original languageHungarian
Pages (from-to)107-121
Number of pages15
JournalIdeggyogyaszati szemle
Volume69
Issue number3-4
DOIs
Publication statusPublished - márc. 30 2016

Keywords

  • EEG
  • Idiopathic generalized epilepsies
  • Individual diagnosis
  • LORETA

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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