Egyedi LORETA-abnormalitások vizsgálata idiopathiás generalizált epilepsziákban

B. Clemens, Szilvia Puskás, Mónika Besenyei, I. Kondákor, Katalin Hollódy, A. Fogarasi, Katalin Bense, M. Emri, Gábor Opposits, Noémi Zsuzsanna Kovács, I. Fekete

Research output: Article

1 Citation (Scopus)

Abstract

Background: Contemporary neuroimaging methods disclosed structural and functional cerebral abnormalities in idiopathic generalized epilepsies (IGEs). However, individual electrical (EEG) abnormalities have not been evaluated yet in IGE patients. Methods: IGE patients were investigated in the drug-free condition and after 3-6 month of antiepileptic treatment. To estimate the reproducibility of qEEG, variables a retrospective recruited cohort of IGE patients was investigated. 19-channel resting state EEG activity was recorded. For each patient a total of 2 minutes EEG activity was analyzed by LORETA (Low Resolution Electromagnetic Tomography). Raw LORETA values were Z-transformed and projected to a MRI template. Z-values outside within the [+3Z] to [-3Z] range were labelled as statistically abnormal. Results: 1. In drug-free condition, 41-50% of IGE patients showed abnormal LORETA values. 2. Abnormal LORETA findings showed great inter-individual variability. 3. Most abnormal LORETA-findings were symmetrical. 4. Most maximum Z-values were localized to frontal or temporal cortex. 5. Succesfull treatment was mostly coupled with disappearence of LORETA-abnormality, persistent seizures were accompanied by persistent LORETA abnormality. Discussion: 1. LORETA abnormalities detected in the untreated condition reflect seizure-generating property of the cortex in IGE patients. 2. Maximum LORETA-Z abnormalities were topographically congruent with structural abnormalities reported by other research groups. 3. LORE-TA might help to investigate drug effects at the whole-brain level.

Original languageHungarian
Pages (from-to)107-121
Number of pages15
JournalIdeggyógyászati szemle
Volume69
Issue number3-4
DOIs
Publication statusPublished - márc. 30 2016

Fingerprint

Electromagnetic Phenomena
Tomography
Electroencephalography
Seizures
Pharmaceutical Preparations
Idiopathic Generalized Epilepsy
Frontal Lobe
Temporal Lobe
Neuroimaging
Anticonvulsants
Brain
Therapeutics

Keywords

  • EEG
  • Idiopathic generalized epilepsies
  • Individual diagnosis
  • LORETA

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Medicine(all)

Cite this

Egyedi LORETA-abnormalitások vizsgálata idiopathiás generalizált epilepsziákban. / Clemens, B.; Puskás, Szilvia; Besenyei, Mónika; Kondákor, I.; Hollódy, Katalin; Fogarasi, A.; Bense, Katalin; Emri, M.; Opposits, Gábor; Kovács, Noémi Zsuzsanna; Fekete, I.

In: Ideggyógyászati szemle, Vol. 69, No. 3-4, 30.03.2016, p. 107-121.

Research output: Article

Clemens, B. ; Puskás, Szilvia ; Besenyei, Mónika ; Kondákor, I. ; Hollódy, Katalin ; Fogarasi, A. ; Bense, Katalin ; Emri, M. ; Opposits, Gábor ; Kovács, Noémi Zsuzsanna ; Fekete, I. / Egyedi LORETA-abnormalitások vizsgálata idiopathiás generalizált epilepsziákban. In: Ideggyógyászati szemle. 2016 ; Vol. 69, No. 3-4. pp. 107-121.
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abstract = "Background: Contemporary neuroimaging methods disclosed structural and functional cerebral abnormalities in idiopathic generalized epilepsies (IGEs). However, individual electrical (EEG) abnormalities have not been evaluated yet in IGE patients. Methods: IGE patients were investigated in the drug-free condition and after 3-6 month of antiepileptic treatment. To estimate the reproducibility of qEEG, variables a retrospective recruited cohort of IGE patients was investigated. 19-channel resting state EEG activity was recorded. For each patient a total of 2 minutes EEG activity was analyzed by LORETA (Low Resolution Electromagnetic Tomography). Raw LORETA values were Z-transformed and projected to a MRI template. Z-values outside within the [+3Z] to [-3Z] range were labelled as statistically abnormal. Results: 1. In drug-free condition, 41-50{\%} of IGE patients showed abnormal LORETA values. 2. Abnormal LORETA findings showed great inter-individual variability. 3. Most abnormal LORETA-findings were symmetrical. 4. Most maximum Z-values were localized to frontal or temporal cortex. 5. Succesfull treatment was mostly coupled with disappearence of LORETA-abnormality, persistent seizures were accompanied by persistent LORETA abnormality. Discussion: 1. LORETA abnormalities detected in the untreated condition reflect seizure-generating property of the cortex in IGE patients. 2. Maximum LORETA-Z abnormalities were topographically congruent with structural abnormalities reported by other research groups. 3. LORE-TA might help to investigate drug effects at the whole-brain level.",
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T1 - Egyedi LORETA-abnormalitások vizsgálata idiopathiás generalizált epilepsziákban

AU - Clemens, B.

AU - Puskás, Szilvia

AU - Besenyei, Mónika

AU - Kondákor, I.

AU - Hollódy, Katalin

AU - Fogarasi, A.

AU - Bense, Katalin

AU - Emri, M.

AU - Opposits, Gábor

AU - Kovács, Noémi Zsuzsanna

AU - Fekete, I.

PY - 2016/3/30

Y1 - 2016/3/30

N2 - Background: Contemporary neuroimaging methods disclosed structural and functional cerebral abnormalities in idiopathic generalized epilepsies (IGEs). However, individual electrical (EEG) abnormalities have not been evaluated yet in IGE patients. Methods: IGE patients were investigated in the drug-free condition and after 3-6 month of antiepileptic treatment. To estimate the reproducibility of qEEG, variables a retrospective recruited cohort of IGE patients was investigated. 19-channel resting state EEG activity was recorded. For each patient a total of 2 minutes EEG activity was analyzed by LORETA (Low Resolution Electromagnetic Tomography). Raw LORETA values were Z-transformed and projected to a MRI template. Z-values outside within the [+3Z] to [-3Z] range were labelled as statistically abnormal. Results: 1. In drug-free condition, 41-50% of IGE patients showed abnormal LORETA values. 2. Abnormal LORETA findings showed great inter-individual variability. 3. Most abnormal LORETA-findings were symmetrical. 4. Most maximum Z-values were localized to frontal or temporal cortex. 5. Succesfull treatment was mostly coupled with disappearence of LORETA-abnormality, persistent seizures were accompanied by persistent LORETA abnormality. Discussion: 1. LORETA abnormalities detected in the untreated condition reflect seizure-generating property of the cortex in IGE patients. 2. Maximum LORETA-Z abnormalities were topographically congruent with structural abnormalities reported by other research groups. 3. LORE-TA might help to investigate drug effects at the whole-brain level.

AB - Background: Contemporary neuroimaging methods disclosed structural and functional cerebral abnormalities in idiopathic generalized epilepsies (IGEs). However, individual electrical (EEG) abnormalities have not been evaluated yet in IGE patients. Methods: IGE patients were investigated in the drug-free condition and after 3-6 month of antiepileptic treatment. To estimate the reproducibility of qEEG, variables a retrospective recruited cohort of IGE patients was investigated. 19-channel resting state EEG activity was recorded. For each patient a total of 2 minutes EEG activity was analyzed by LORETA (Low Resolution Electromagnetic Tomography). Raw LORETA values were Z-transformed and projected to a MRI template. Z-values outside within the [+3Z] to [-3Z] range were labelled as statistically abnormal. Results: 1. In drug-free condition, 41-50% of IGE patients showed abnormal LORETA values. 2. Abnormal LORETA findings showed great inter-individual variability. 3. Most abnormal LORETA-findings were symmetrical. 4. Most maximum Z-values were localized to frontal or temporal cortex. 5. Succesfull treatment was mostly coupled with disappearence of LORETA-abnormality, persistent seizures were accompanied by persistent LORETA abnormality. Discussion: 1. LORETA abnormalities detected in the untreated condition reflect seizure-generating property of the cortex in IGE patients. 2. Maximum LORETA-Z abnormalities were topographically congruent with structural abnormalities reported by other research groups. 3. LORE-TA might help to investigate drug effects at the whole-brain level.

KW - EEG

KW - Idiopathic generalized epilepsies

KW - Individual diagnosis

KW - LORETA

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