Individual and combined effects of fumonisin B1, deoxynivalenol and zearalenone on the hepatic and renal membrane lipid integrity of rats

András Szabó, Judit Szabó-Fodor, Hedvig Fébel, Miklós Mézes, Krisztián Balogh, György Bázár, Dániel Kocsó, Omeralfaroug Ali, Melinda Kovács

Research output: Article

14 Citations (Scopus)


(1) Background and (2) Methods: A 14-day in vivo, multitoxic (pure mycotoxins) rat experiment was conducted with zearalenone (ZEA; 15 µg/animal/day), deoxynivalenol (DON; 30 µg/animal/day) and fumonisin B1 (FB1; 150 µg/animal/day), as individual mycotoxins, binary (FD, FZ and DZ) and ternary combinations (FDZ), via gavage in 1 mL water boluses. (3) Results: Body weight was unaffected, while liver (ZEA↑ vs. DON) and kidney weight (ZEA↑ vs. FDZ) increased. Hepatocellular membrane lipid fatty acids (FAs) referred to ceramide synthesis disturbance (C20:0, C22:0), and decreased unsaturation (C22:5 n3 and unsat. index), mainly induced by DON and to a lesser extent by ZEA. The DON-FB1 interaction was additive on C20:0 in liver lipids. In renal phospholipids, ZEA had the strongest effect on the FA profile, affecting the saturated (C18:0) and many n6 FAs; ZEA was in an antagonistic relationship with FB1 (C18:0) or DON (C18:2 n6, C20:1 n9). Hepatic oxidative stress was the most expressed in FD (reduced glutathione and glutathione peroxidase), while the nephrotoxic effect was further supported by lipid peroxidation (malondialdehyde) in the DON treatment. (4) Conclusions: In vivo study results refer to multiple mycotoxin interactions on membrane FAs, antioxidants and lipid peroxidation compounds, needing further testing.

Original languageEnglish
Article number4
Issue number1
Publication statusPublished - jan. 2018

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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