During the last years the trend in drug discovery has been to produce more and more compounds that exhibit high lipophilicity and poor water solubility. If a drug candidate has reasonable membrane permeability - the pharmacon belongs to the second group of the biopharmaceutical classification system (BCS) - then often the rate-limiting process of absorption is the drug dissolution step. There are a number of formulation strategies that could be used to improve the bioavailability of these materials. In this article the author would like to collect the technological possibilities, and gives some samples from the results of the research group of the Department cf Pharmaceutical Technology, University of Szeged.
|Number of pages||8|
|Journal||Acta pharmaceutica Hungarica|
|Publication status||Published - ápr. 11 2008|
ASJC Scopus subject areas
- Pharmaceutical Science