Increased take rate of human tumour xenografts after Carragheenan treatment

L. Kopper, Tran Van Hanh, K. Lapis, J. Timár

Research output: Article

14 Citations (Scopus)

Abstract

Experiments are reported in which attempts were made to improve the take-rate of human tumour xenografts by inhibiting macrophages. Carragheenan, a macrophage-toxic agent was used in a dose of 5 mg/mouse i.p. Results showed that Carragheenan inhibited the functional activity of peritoneal macrophages both in normal and immune-suppressed mice. The take-rate of three serially transplanted human colorectal xenograft lines increased when the transplantation was made into immune-suppressed mice treated with Carragheenan 1 day before tumour grafting.

Original languageEnglish
Pages (from-to)671-673,675-678
JournalEuropean Journal of Cancer (1965)
Volume16
Issue number5
DOIs
Publication statusPublished - máj. 1980

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ASJC Scopus subject areas

  • Medicine(all)

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