Experiments are reported in which attempts were made to improve the take-rate of human tumour xenografts by inhibiting macrophages. Carragheenan, a macrophage-toxic agent was used in a dose of 5 mg/mouse i.p. Results showed that Carragheenan inhibited the functional activity of peritoneal macrophages both in normal and immune-suppressed mice. The take-rate of three serially transplanted human colorectal xenograft lines increased when the transplantation was made into immune-suppressed mice treated with Carragheenan 1 day before tumour grafting.
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