Increased resting-state EEG functional connectivity in benign childhood epilepsy with centro-temporal spikes

B. Clemens, Szilvia Puskás, Tamás Spisák, Imre Lajtos, Gábor Opposits, Mónika Besenyei, Katalin Hollódy, A. Fogarasi, Noémi Zsuzsanna Kovács, I. Fekete, M. Emri

Research output: Article

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Abstract

Purpose To explore intrahemispheric, cortico-cortical EEG functional connectivity (EEGfC) in benign childhood epilepsy with rolandic spikes (BECTS). Methods 21-channel EEG was recorded in 17 non-medicated BECTS children and 19 healthy controls. 180 s of spike- and artifact-free activity was selected for EEGfC analysis. Correlation of Low Resolution Electromagnetic Tomography- (LORETA-) defined current source density time series were computed between two cortical areas (region of interest, ROI). Analyses were based on broad-band EEGfC results. Groups were compared by statistical parametric network (SPN) method. Statistically significant differences between group EEGfC values were emphasized at p <0.05 corrected for multiple comparison by local false discovery rate (FDR). Results (1) Bilaterally increased beta EEGfC occurred in the BECTS group as compared to the controls. Greatest beta abnormality emerged between frontal and frontal, as well as frontal and temporal ROIs. (2) Locally increased EEGfC emerged in all frequency bands in the right parietal area. Conclusions Areas of increased EEGfC topographically correspond to cortical areas that, based on relevant literature, are related to speech and attention deficit in BECTS children.

Original languageEnglish
Pages (from-to)50-55
Number of pages6
JournalSeizure
Volume35
DOIs
Publication statusPublished - febr. 1 2016

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Rolandic Epilepsy
Electroencephalography
Electromagnetic Phenomena
Artifacts
Tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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Increased resting-state EEG functional connectivity in benign childhood epilepsy with centro-temporal spikes. / Clemens, B.; Puskás, Szilvia; Spisák, Tamás; Lajtos, Imre; Opposits, Gábor; Besenyei, Mónika; Hollódy, Katalin; Fogarasi, A.; Kovács, Noémi Zsuzsanna; Fekete, I.; Emri, M.

In: Seizure, Vol. 35, 01.02.2016, p. 50-55.

Research output: Article

Clemens, B. ; Puskás, Szilvia ; Spisák, Tamás ; Lajtos, Imre ; Opposits, Gábor ; Besenyei, Mónika ; Hollódy, Katalin ; Fogarasi, A. ; Kovács, Noémi Zsuzsanna ; Fekete, I. ; Emri, M. / Increased resting-state EEG functional connectivity in benign childhood epilepsy with centro-temporal spikes. In: Seizure. 2016 ; Vol. 35. pp. 50-55.
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AU - Puskás, Szilvia

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AU - Opposits, Gábor

AU - Besenyei, Mónika

AU - Hollódy, Katalin

AU - Fogarasi, A.

AU - Kovács, Noémi Zsuzsanna

AU - Fekete, I.

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N2 - Purpose To explore intrahemispheric, cortico-cortical EEG functional connectivity (EEGfC) in benign childhood epilepsy with rolandic spikes (BECTS). Methods 21-channel EEG was recorded in 17 non-medicated BECTS children and 19 healthy controls. 180 s of spike- and artifact-free activity was selected for EEGfC analysis. Correlation of Low Resolution Electromagnetic Tomography- (LORETA-) defined current source density time series were computed between two cortical areas (region of interest, ROI). Analyses were based on broad-band EEGfC results. Groups were compared by statistical parametric network (SPN) method. Statistically significant differences between group EEGfC values were emphasized at p <0.05 corrected for multiple comparison by local false discovery rate (FDR). Results (1) Bilaterally increased beta EEGfC occurred in the BECTS group as compared to the controls. Greatest beta abnormality emerged between frontal and frontal, as well as frontal and temporal ROIs. (2) Locally increased EEGfC emerged in all frequency bands in the right parietal area. Conclusions Areas of increased EEGfC topographically correspond to cortical areas that, based on relevant literature, are related to speech and attention deficit in BECTS children.

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