Increased incidence of genetic human prion disease in Hungary

G. G. Kovács, L. László, A. Bakos, J. Minárovits, M. T. Bishop, T. Ströbel, B. Vajna, E. Mitrova, K. Majtényi

Research output: Article

15 Citations (Scopus)

Abstract

The authors performed analysis of the prion protein gene (PRNP) in 27 out of 109 confirmed prion disease patients between 1994 and 2004. E200K mutation was found in 17 cases. Another 10 patients, lacking PRNP analysis, showed positive family history. The mean annual incidence (0.27/ million) and proportion (25.6%) of genetic prion disease is unusually high in Hungary and might be related to the migration of ancestors from the Slovakian focus.

Original languageEnglish
Pages (from-to)1666-1669
Number of pages4
JournalNeurology
Volume65
Issue number10
DOIs
Publication statusPublished - nov. 2005

ASJC Scopus subject areas

  • Clinical Neurology

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