Incidence, paris classification, and follow-up in a nationwide incident cohort of pediatric patients with inflammatory bowel disease

Katalin E. Müller, P. Lakatos, A. Arató, J. Kovács, A. Várkonyi, Dániel Szucs, Erzsébet Szakos, Eniko Sólyom, Márta Kovács, Marianne Polgár, E. Nemes, Ildikó Guthy, István Tokodi, Gergely Tóth, Ágnes Horváth, András Tárnok, Noémi Csoszánszki, Márta Balogh, Noémi Vass, Piroska Bódi & 25 others Antal Dezsofi, László Gárdos, Éva Micskey, M. Papp, Áron Cseh, Dolóresz Szabó, Péter Vörös, G. Verès, Ildikó Kis, Éva Pollák, Ildikó Rosta, Károly Schultz, Ferenc Harangi, Katalin Szabados, Erzsébet Szathmári, Judit Czelecz, Katalin Szigeti, Katalin Tamás, András Tóth, Éva Vajdovich, Gabriella Tomcsa, Erika Tomsits, Kriszta Molnár, Petra A. Golovics, Barbara D. Lovász

Research output: Article

58 Citations (Scopus)

Abstract

OBJECTIVES:: The aim of the study was to evaluate the incidence, baseline disease characteristics, and disease location based on the Paris classification in pediatric inflammatory bowel disease (IBD) in the Hungarian nationwide inception cohort. In addition, 1-year follow-up with therapy was analyzed. METHODS:: From January 1, 2007 to December 31, 2009, newly diagnosed pediatric patients with IBD were prospectively registered. Twenty-seven pediatric gastroenterology centers participated in the data collection ensuring the data from the whole country. Newly diagnosed patients with IBD younger than 18 years were reported. Disease location was classified according to the Paris classification. RESULTS:: A total of 420 patients were identified. The incidence rate of pediatric IBD was 7.48/10 (95% confidence interval [CI] 6.34/10-8.83/10). The incidence for Crohn disease (CD) was 4.72/10 (95% CI 3.82-5.79), for ulcerative colitis (UC) 2.32/10 (95% CI 1.71-3.09), and for IBD-unclassified 0.45/10 (95% CI 0.22-0.84). Most common location in CD was L3 (58.7%); typical upper gastrointestinal abnormalities (ulcer, erosion and aphthous lesion) were observed in 29.9%. Extensive colitis in patients with UC (E4, proximal to hepatic flexure) was the most common disease phenotype (57%), whereas only 5% of children had proctitis. A total of 18.6% of patients had ever severe disease (S1). Frequency of azathioprine administration at diagnosis was 29.5% in patients with CD, and this rate increased to 54.6% (130/238) at 1-year follow-up. In UC, only 3.3% received azathioprine initially, and this rate elevated to 22.5% (25/111). Use of corticosteroid decreased from 50% to 15.3% in patients with UC. Rate of bowel resection in patients with CD during the first year of follow-up was 5%. CONCLUSIONS:: The incidence of pediatric IBD in Hungary was among the higher range reported. This is the first large, nationwide incident cohort analyzed according to the Paris classification, which is a useful tool to determine the characteristic pediatric CD phenotype.

Original languageEnglish
Pages (from-to)576-582
Number of pages7
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume57
Issue number5
DOIs
Publication statusPublished - nov. 2013

Fingerprint

Paris
Inflammatory Bowel Diseases
Pediatrics
Incidence
Ulcerative Colitis
Crohn Disease
Confidence Intervals
Azathioprine
Proctitis
Aphthous Stomatitis
Phenotype
Hungary
Gastroenterology
Colitis
Adrenal Cortex Hormones
Liver

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Cite this

Incidence, paris classification, and follow-up in a nationwide incident cohort of pediatric patients with inflammatory bowel disease. / Müller, Katalin E.; Lakatos, P.; Arató, A.; Kovács, J.; Várkonyi, A.; Szucs, Dániel; Szakos, Erzsébet; Sólyom, Eniko; Kovács, Márta; Polgár, Marianne; Nemes, E.; Guthy, Ildikó; Tokodi, István; Tóth, Gergely; Horváth, Ágnes; Tárnok, András; Csoszánszki, Noémi; Balogh, Márta; Vass, Noémi; Bódi, Piroska; Dezsofi, Antal; Gárdos, László; Micskey, Éva; Papp, M.; Cseh, Áron; Szabó, Dolóresz; Vörös, Péter; Verès, G.; Kis, Ildikó; Pollák, Éva; Rosta, Ildikó; Schultz, Károly; Harangi, Ferenc; Szabados, Katalin; Szathmári, Erzsébet; Czelecz, Judit; Szigeti, Katalin; Tamás, Katalin; Tóth, András; Vajdovich, Éva; Tomcsa, Gabriella; Tomsits, Erika; Molnár, Kriszta; Golovics, Petra A.; Lovász, Barbara D.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 57, No. 5, 11.2013, p. 576-582.

Research output: Article

Müller, KE, Lakatos, P, Arató, A, Kovács, J, Várkonyi, A, Szucs, D, Szakos, E, Sólyom, E, Kovács, M, Polgár, M, Nemes, E, Guthy, I, Tokodi, I, Tóth, G, Horváth, Á, Tárnok, A, Csoszánszki, N, Balogh, M, Vass, N, Bódi, P, Dezsofi, A, Gárdos, L, Micskey, É, Papp, M, Cseh, Á, Szabó, D, Vörös, P, Verès, G, Kis, I, Pollák, É, Rosta, I, Schultz, K, Harangi, F, Szabados, K, Szathmári, E, Czelecz, J, Szigeti, K, Tamás, K, Tóth, A, Vajdovich, É, Tomcsa, G, Tomsits, E, Molnár, K, Golovics, PA & Lovász, BD 2013, 'Incidence, paris classification, and follow-up in a nationwide incident cohort of pediatric patients with inflammatory bowel disease', Journal of Pediatric Gastroenterology and Nutrition, vol. 57, no. 5, pp. 576-582. https://doi.org/10.1097/MPG.0b013e31829f7d8c
Müller, Katalin E. ; Lakatos, P. ; Arató, A. ; Kovács, J. ; Várkonyi, A. ; Szucs, Dániel ; Szakos, Erzsébet ; Sólyom, Eniko ; Kovács, Márta ; Polgár, Marianne ; Nemes, E. ; Guthy, Ildikó ; Tokodi, István ; Tóth, Gergely ; Horváth, Ágnes ; Tárnok, András ; Csoszánszki, Noémi ; Balogh, Márta ; Vass, Noémi ; Bódi, Piroska ; Dezsofi, Antal ; Gárdos, László ; Micskey, Éva ; Papp, M. ; Cseh, Áron ; Szabó, Dolóresz ; Vörös, Péter ; Verès, G. ; Kis, Ildikó ; Pollák, Éva ; Rosta, Ildikó ; Schultz, Károly ; Harangi, Ferenc ; Szabados, Katalin ; Szathmári, Erzsébet ; Czelecz, Judit ; Szigeti, Katalin ; Tamás, Katalin ; Tóth, András ; Vajdovich, Éva ; Tomcsa, Gabriella ; Tomsits, Erika ; Molnár, Kriszta ; Golovics, Petra A. ; Lovász, Barbara D. / Incidence, paris classification, and follow-up in a nationwide incident cohort of pediatric patients with inflammatory bowel disease. In: Journal of Pediatric Gastroenterology and Nutrition. 2013 ; Vol. 57, No. 5. pp. 576-582.
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abstract = "OBJECTIVES:: The aim of the study was to evaluate the incidence, baseline disease characteristics, and disease location based on the Paris classification in pediatric inflammatory bowel disease (IBD) in the Hungarian nationwide inception cohort. In addition, 1-year follow-up with therapy was analyzed. METHODS:: From January 1, 2007 to December 31, 2009, newly diagnosed pediatric patients with IBD were prospectively registered. Twenty-seven pediatric gastroenterology centers participated in the data collection ensuring the data from the whole country. Newly diagnosed patients with IBD younger than 18 years were reported. Disease location was classified according to the Paris classification. RESULTS:: A total of 420 patients were identified. The incidence rate of pediatric IBD was 7.48/10 (95{\%} confidence interval [CI] 6.34/10-8.83/10). The incidence for Crohn disease (CD) was 4.72/10 (95{\%} CI 3.82-5.79), for ulcerative colitis (UC) 2.32/10 (95{\%} CI 1.71-3.09), and for IBD-unclassified 0.45/10 (95{\%} CI 0.22-0.84). Most common location in CD was L3 (58.7{\%}); typical upper gastrointestinal abnormalities (ulcer, erosion and aphthous lesion) were observed in 29.9{\%}. Extensive colitis in patients with UC (E4, proximal to hepatic flexure) was the most common disease phenotype (57{\%}), whereas only 5{\%} of children had proctitis. A total of 18.6{\%} of patients had ever severe disease (S1). Frequency of azathioprine administration at diagnosis was 29.5{\%} in patients with CD, and this rate increased to 54.6{\%} (130/238) at 1-year follow-up. In UC, only 3.3{\%} received azathioprine initially, and this rate elevated to 22.5{\%} (25/111). Use of corticosteroid decreased from 50{\%} to 15.3{\%} in patients with UC. Rate of bowel resection in patients with CD during the first year of follow-up was 5{\%}. CONCLUSIONS:: The incidence of pediatric IBD in Hungary was among the higher range reported. This is the first large, nationwide incident cohort analyzed according to the Paris classification, which is a useful tool to determine the characteristic pediatric CD phenotype.",
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TY - JOUR

T1 - Incidence, paris classification, and follow-up in a nationwide incident cohort of pediatric patients with inflammatory bowel disease

AU - Müller, Katalin E.

AU - Lakatos, P.

AU - Arató, A.

AU - Kovács, J.

AU - Várkonyi, A.

AU - Szucs, Dániel

AU - Szakos, Erzsébet

AU - Sólyom, Eniko

AU - Kovács, Márta

AU - Polgár, Marianne

AU - Nemes, E.

AU - Guthy, Ildikó

AU - Tokodi, István

AU - Tóth, Gergely

AU - Horváth, Ágnes

AU - Tárnok, András

AU - Csoszánszki, Noémi

AU - Balogh, Márta

AU - Vass, Noémi

AU - Bódi, Piroska

AU - Dezsofi, Antal

AU - Gárdos, László

AU - Micskey, Éva

AU - Papp, M.

AU - Cseh, Áron

AU - Szabó, Dolóresz

AU - Vörös, Péter

AU - Verès, G.

AU - Kis, Ildikó

AU - Pollák, Éva

AU - Rosta, Ildikó

AU - Schultz, Károly

AU - Harangi, Ferenc

AU - Szabados, Katalin

AU - Szathmári, Erzsébet

AU - Czelecz, Judit

AU - Szigeti, Katalin

AU - Tamás, Katalin

AU - Tóth, András

AU - Vajdovich, Éva

AU - Tomcsa, Gabriella

AU - Tomsits, Erika

AU - Molnár, Kriszta

AU - Golovics, Petra A.

AU - Lovász, Barbara D.

PY - 2013/11

Y1 - 2013/11

N2 - OBJECTIVES:: The aim of the study was to evaluate the incidence, baseline disease characteristics, and disease location based on the Paris classification in pediatric inflammatory bowel disease (IBD) in the Hungarian nationwide inception cohort. In addition, 1-year follow-up with therapy was analyzed. METHODS:: From January 1, 2007 to December 31, 2009, newly diagnosed pediatric patients with IBD were prospectively registered. Twenty-seven pediatric gastroenterology centers participated in the data collection ensuring the data from the whole country. Newly diagnosed patients with IBD younger than 18 years were reported. Disease location was classified according to the Paris classification. RESULTS:: A total of 420 patients were identified. The incidence rate of pediatric IBD was 7.48/10 (95% confidence interval [CI] 6.34/10-8.83/10). The incidence for Crohn disease (CD) was 4.72/10 (95% CI 3.82-5.79), for ulcerative colitis (UC) 2.32/10 (95% CI 1.71-3.09), and for IBD-unclassified 0.45/10 (95% CI 0.22-0.84). Most common location in CD was L3 (58.7%); typical upper gastrointestinal abnormalities (ulcer, erosion and aphthous lesion) were observed in 29.9%. Extensive colitis in patients with UC (E4, proximal to hepatic flexure) was the most common disease phenotype (57%), whereas only 5% of children had proctitis. A total of 18.6% of patients had ever severe disease (S1). Frequency of azathioprine administration at diagnosis was 29.5% in patients with CD, and this rate increased to 54.6% (130/238) at 1-year follow-up. In UC, only 3.3% received azathioprine initially, and this rate elevated to 22.5% (25/111). Use of corticosteroid decreased from 50% to 15.3% in patients with UC. Rate of bowel resection in patients with CD during the first year of follow-up was 5%. CONCLUSIONS:: The incidence of pediatric IBD in Hungary was among the higher range reported. This is the first large, nationwide incident cohort analyzed according to the Paris classification, which is a useful tool to determine the characteristic pediatric CD phenotype.

AB - OBJECTIVES:: The aim of the study was to evaluate the incidence, baseline disease characteristics, and disease location based on the Paris classification in pediatric inflammatory bowel disease (IBD) in the Hungarian nationwide inception cohort. In addition, 1-year follow-up with therapy was analyzed. METHODS:: From January 1, 2007 to December 31, 2009, newly diagnosed pediatric patients with IBD were prospectively registered. Twenty-seven pediatric gastroenterology centers participated in the data collection ensuring the data from the whole country. Newly diagnosed patients with IBD younger than 18 years were reported. Disease location was classified according to the Paris classification. RESULTS:: A total of 420 patients were identified. The incidence rate of pediatric IBD was 7.48/10 (95% confidence interval [CI] 6.34/10-8.83/10). The incidence for Crohn disease (CD) was 4.72/10 (95% CI 3.82-5.79), for ulcerative colitis (UC) 2.32/10 (95% CI 1.71-3.09), and for IBD-unclassified 0.45/10 (95% CI 0.22-0.84). Most common location in CD was L3 (58.7%); typical upper gastrointestinal abnormalities (ulcer, erosion and aphthous lesion) were observed in 29.9%. Extensive colitis in patients with UC (E4, proximal to hepatic flexure) was the most common disease phenotype (57%), whereas only 5% of children had proctitis. A total of 18.6% of patients had ever severe disease (S1). Frequency of azathioprine administration at diagnosis was 29.5% in patients with CD, and this rate increased to 54.6% (130/238) at 1-year follow-up. In UC, only 3.3% received azathioprine initially, and this rate elevated to 22.5% (25/111). Use of corticosteroid decreased from 50% to 15.3% in patients with UC. Rate of bowel resection in patients with CD during the first year of follow-up was 5%. CONCLUSIONS:: The incidence of pediatric IBD in Hungary was among the higher range reported. This is the first large, nationwide incident cohort analyzed according to the Paris classification, which is a useful tool to determine the characteristic pediatric CD phenotype.

KW - Crohn disease

KW - epidemiology

KW - pediatric inflammatory bowel disease

KW - therapy

KW - ulcerative colitis

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