A faktor V G1691A (Leiden) mutáció gyakorisága magyar népességmintákban.

J. Stankovics, B. Melegh, A. Nagy, A. Kis, J. Molnár, H. Losonczy, A. Schuler, G. Kosztolányi

Research output: Article

7 Citations (Scopus)

Abstract

Thromboembolic disorders affect 0.1% of the adult population. Two main groups of the underlying predisposition factors can be identified: environmental factors (e.g. dietary habits, physical activity, surgical interventions, pregnancy etc.) and several genetic predispositions (e.g. inherited anticoagulant defects). After the discovery of the genetic mutation of factor V, called Leiden mutation, it turned out, that this mutation is responsible for the development of resistance to activated protein C in majority of the cases. The importance of the Leiden mutation is further emphasised by population based investigations, which makes it the most frequent thrombosis risk factor known today. In our study we have identified 43 heterozygotes and 3 homozygotes with Leiden mutation in total of 665 samples. The 6.47% heterozigocy is in the range of earlier reports from Europe. The homozygote/heterozygote distribution deviated from the value predicted by the Hardy-Weinberg law.

Original languageHungarian
Pages (from-to)1161-1163
Number of pages3
JournalOrvosi Hetilap
Volume139
Issue number19
Publication statusPublished - máj. 10 1998

Fingerprint

Mutation
Incidence
Population
Homozygote
Heterozygote
Activated Protein C Resistance
Feeding Behavior
Genetic Predisposition to Disease
Anticoagulants
Thrombosis
factor V Leiden
Pregnancy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Stankovics, J., Melegh, B., Nagy, A., Kis, A., Molnár, J., Losonczy, H., ... Kosztolányi, G. (1998). A faktor V G1691A (Leiden) mutáció gyakorisága magyar népességmintákban. Orvosi Hetilap, 139(19), 1161-1163.

A faktor V G1691A (Leiden) mutáció gyakorisága magyar népességmintákban. / Stankovics, J.; Melegh, B.; Nagy, A.; Kis, A.; Molnár, J.; Losonczy, H.; Schuler, A.; Kosztolányi, G.

In: Orvosi Hetilap, Vol. 139, No. 19, 10.05.1998, p. 1161-1163.

Research output: Article

Stankovics, J, Melegh, B, Nagy, A, Kis, A, Molnár, J, Losonczy, H, Schuler, A & Kosztolányi, G 1998, 'A faktor V G1691A (Leiden) mutáció gyakorisága magyar népességmintákban.', Orvosi Hetilap, vol. 139, no. 19, pp. 1161-1163.
Stankovics J, Melegh B, Nagy A, Kis A, Molnár J, Losonczy H et al. A faktor V G1691A (Leiden) mutáció gyakorisága magyar népességmintákban. Orvosi Hetilap. 1998 máj. 10;139(19):1161-1163.
Stankovics, J. ; Melegh, B. ; Nagy, A. ; Kis, A. ; Molnár, J. ; Losonczy, H. ; Schuler, A. ; Kosztolányi, G. / A faktor V G1691A (Leiden) mutáció gyakorisága magyar népességmintákban. In: Orvosi Hetilap. 1998 ; Vol. 139, No. 19. pp. 1161-1163.
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