Incidence and survival of central nervous system involvement in childhood malignancies: Hungarian experience

Péter Hauser, Zsuzsanna Jakab, Orsolya Láng, Orsolya Kondás, Judit Müller, Dezso Schuler, Lászlo Bognár, Miklós Garami

Research output: Article

11 Citations (Scopus)


Direct extension and hematogenous metastasis of primary non-CNS malignant tumors to the CNS are rare complications in children. The authors analyzed the incidence and outcome of these complications in Hungary. During a 14-year period between 1989 and 2002, 406 patients younger than 18 years were studied at Semmelweis University, Second Department of Pediatrics, in Budapest. Among the 406 patients with non-CNS solid tumors, nine hematogenous metastases and five direct tumor extensions to the CNS occurred. Primary tumors included rhabdomyosarcoma, neuroblastoma, tumors of the Ewing sarcoma family, non-Hodgkin lymphoma, and malignant chordoma. Mean interval between the initial diagnosis and the diagnosis of CNS involvement was 11.4 months. Despite intensive treatment, the mean survival after detection of CNS involvement was 10.4 months. The frequency of CNS involvement in non-CNS tumors is low, with a very poor survival.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Issue number3
Publication statusPublished - márc. 1 2005


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this