In vivo study of the mechanism of protective effects of ascorbic acid and reduced glutathione in paraquat poisoning

B. Matkovics, Katalin Barabás, L. Szabo, G. Berencsi

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22 Citations (Scopus)


1. 1. On the basis of our earlier experiments, in vivo studies were carried out to decide how the optimum concentrations of ascorbic acid and reduced glutathione, administered parenterally at two different times, influence the paraquat LD50 toxicity. 2. 2. Another aim was the molecular biochemical study of their protective effects. 3. 3. It was found that both substances influence the in vivo action of paraquat, but they are not able fully to prevent or eliminate them. 4. 4. The positive detoxicating effect of ascorbic acid may be emphasized.

Original languageEnglish
Pages (from-to)455-461
Number of pages7
JournalGeneral Pharmacology
Issue number5
Publication statusPublished - 1980


ASJC Scopus subject areas

  • Pharmacology

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