Impaired T cell functions preceding lymphoproliferative disorders in mice neonatally tolerized to transplantation antigens.

T. Jánossy, C. Vízler, I. Ocsovszki, G. J. Tibbe, J. Pipis, H. F. Savelkoul, P. Végh, R. Benner

Research output: Article

Abstract

In A/J (H-2a) (A) mice, the neonatal i.v. injection of (B10 x A)F1 spleen cells (SC) induces partial transplantation tolerance (TT) to C57BL/10ScSn (H-2b) (B10) skin allografts, chronic host-versus-graft disease (HVGD) and lethal lymphoproliferative disorders (LPD). They produce anti-T-cell autoantibodies (ATA), and the proliferative responses of their SC to the T cell mitogen Con A are decreased. We found that, similar to ATA, the hyporeactivity of T cells developed earlier (at 1-2 weeks of age) than splenomegaly. The proportions of both CD4+ and CD8+ T cells were not reduced in the spleens of tolerized mice without manifest LPD. The supernatants (SN) of Con A-stimulated tolerized SC contained no, or only small amounts of interleukin-2 (IL-2). Thus, in the tolerized mice, ATA and T cell deficiency preceded the development of LPD. ATA and the decreased amount of the T cell growth factor IL-2 might play a role in the defective T cell activation.

Original languageEnglish
Pages (from-to)150-151
Number of pages2
JournalActa Chirurgica Hungarica
Volume36
Issue number1-4
Publication statusPublished - 1997

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Histocompatibility Antigens
Lymphoproliferative Disorders
T-Lymphocytes
Autoantibodies
Spleen
Interleukin-2
Transplantation Tolerance
Splenomegaly
Graft vs Host Disease
Mitogens
Allografts
Skin
Injections
Thomsen-Friedenreich antibodies

ASJC Scopus subject areas

  • Surgery

Cite this

Impaired T cell functions preceding lymphoproliferative disorders in mice neonatally tolerized to transplantation antigens. / Jánossy, T.; Vízler, C.; Ocsovszki, I.; Tibbe, G. J.; Pipis, J.; Savelkoul, H. F.; Végh, P.; Benner, R.

In: Acta Chirurgica Hungarica, Vol. 36, No. 1-4, 1997, p. 150-151.

Research output: Article

Jánossy, T. ; Vízler, C. ; Ocsovszki, I. ; Tibbe, G. J. ; Pipis, J. ; Savelkoul, H. F. ; Végh, P. ; Benner, R. / Impaired T cell functions preceding lymphoproliferative disorders in mice neonatally tolerized to transplantation antigens. In: Acta Chirurgica Hungarica. 1997 ; Vol. 36, No. 1-4. pp. 150-151.
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AU - Jánossy, T.

AU - Vízler, C.

AU - Ocsovszki, I.

AU - Tibbe, G. J.

AU - Pipis, J.

AU - Savelkoul, H. F.

AU - Végh, P.

AU - Benner, R.

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