Impact of CT-apelin and NT-proBNP on identifying non-responders to cardiac resynchronization therapy

Annamária Kosztin, G. Széplaki, Attila Kovács, Gábor Földes, I. Szokodi, Klaudia Vivien Nagy, Valentina Kutyifa, Éva Fórizs, Eszter M. Végh, L. Gellér, Dávid Becker, D. Aradi, B. Merkely

Research output: Article

Abstract

Context: Assessment of response to cardiac resynchronization therapy (CRT) is essential. Objective: To assess the predictive value of CT-apelin together with NT-proBNP in patients undergoing CRT. Methods: Serum CT-apelin and NT-proBNP were measured by ELISA before, and six months after CRT. Primary endpoint was non-response (<4% increase in LVEF) after six months. Results: From 81 patients, 15 proved to be non-responders. Six-month CT-apelin was superior compared to NT-proBNP in identifying non-responders by multivariate ROC (CT-apelin: p = 0.01, NT-proBNP: p = 0.13) and by logistic regression (CT-apelin: p = 0.01, NT-proBNP: p = 0.41) analyses. Conclusion: Six-month CT-apelin might be a valuable novel biomarker in identifying non-responders to CRT that was superior to NT-proBNP.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalBiomarkers
DOIs
Publication statusAccepted/In press - aug. 11 2016

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Cardiac resynchronization therapy
Cardiac Resynchronization Therapy
Biomarkers
pro-brain natriuretic peptide (1-76)
Logistics
Logistic Models
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

Impact of CT-apelin and NT-proBNP on identifying non-responders to cardiac resynchronization therapy. / Kosztin, Annamária; Széplaki, G.; Kovács, Attila; Földes, Gábor; Szokodi, I.; Vivien Nagy, Klaudia; Kutyifa, Valentina; Fórizs, Éva; Végh, Eszter M.; Gellér, L.; Becker, Dávid; Aradi, D.; Merkely, B.

In: Biomarkers, 11.08.2016, p. 1-8.

Research output: Article

Kosztin, Annamária ; Széplaki, G. ; Kovács, Attila ; Földes, Gábor ; Szokodi, I. ; Vivien Nagy, Klaudia ; Kutyifa, Valentina ; Fórizs, Éva ; Végh, Eszter M. ; Gellér, L. ; Becker, Dávid ; Aradi, D. ; Merkely, B. / Impact of CT-apelin and NT-proBNP on identifying non-responders to cardiac resynchronization therapy. In: Biomarkers. 2016 ; pp. 1-8.
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abstract = "Context: Assessment of response to cardiac resynchronization therapy (CRT) is essential. Objective: To assess the predictive value of CT-apelin together with NT-proBNP in patients undergoing CRT. Methods: Serum CT-apelin and NT-proBNP were measured by ELISA before, and six months after CRT. Primary endpoint was non-response (<4{\%} increase in LVEF) after six months. Results: From 81 patients, 15 proved to be non-responders. Six-month CT-apelin was superior compared to NT-proBNP in identifying non-responders by multivariate ROC (CT-apelin: p = 0.01, NT-proBNP: p = 0.13) and by logistic regression (CT-apelin: p = 0.01, NT-proBNP: p = 0.41) analyses. Conclusion: Six-month CT-apelin might be a valuable novel biomarker in identifying non-responders to CRT that was superior to NT-proBNP.",
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AU - Kovács, Attila

AU - Földes, Gábor

AU - Szokodi, I.

AU - Vivien Nagy, Klaudia

AU - Kutyifa, Valentina

AU - Fórizs, Éva

AU - Végh, Eszter M.

AU - Gellér, L.

AU - Becker, Dávid

AU - Aradi, D.

AU - Merkely, B.

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N2 - Context: Assessment of response to cardiac resynchronization therapy (CRT) is essential. Objective: To assess the predictive value of CT-apelin together with NT-proBNP in patients undergoing CRT. Methods: Serum CT-apelin and NT-proBNP were measured by ELISA before, and six months after CRT. Primary endpoint was non-response (<4% increase in LVEF) after six months. Results: From 81 patients, 15 proved to be non-responders. Six-month CT-apelin was superior compared to NT-proBNP in identifying non-responders by multivariate ROC (CT-apelin: p = 0.01, NT-proBNP: p = 0.13) and by logistic regression (CT-apelin: p = 0.01, NT-proBNP: p = 0.41) analyses. Conclusion: Six-month CT-apelin might be a valuable novel biomarker in identifying non-responders to CRT that was superior to NT-proBNP.

AB - Context: Assessment of response to cardiac resynchronization therapy (CRT) is essential. Objective: To assess the predictive value of CT-apelin together with NT-proBNP in patients undergoing CRT. Methods: Serum CT-apelin and NT-proBNP were measured by ELISA before, and six months after CRT. Primary endpoint was non-response (<4% increase in LVEF) after six months. Results: From 81 patients, 15 proved to be non-responders. Six-month CT-apelin was superior compared to NT-proBNP in identifying non-responders by multivariate ROC (CT-apelin: p = 0.01, NT-proBNP: p = 0.13) and by logistic regression (CT-apelin: p = 0.01, NT-proBNP: p = 0.41) analyses. Conclusion: Six-month CT-apelin might be a valuable novel biomarker in identifying non-responders to CRT that was superior to NT-proBNP.

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