Imunomodulacijsko zdravljene vnetne črevesne bolezni v pediatriji

Research output: Review article


Immunomodulatory drugs are indispensable in the treatment of children with both Crohn's disease and ulcerative colitis, especially in maintaining remission. Among them, azathioprine and 6-mercaptopurine are the most effective in this respect and they elicit less adverse reactions compared to other immunomodulatory drugs. A very important benefit of immunomodulatory therapy is that they are steroid-sparing agents, which is especially essential in developing children. Although, due to their slow onset of action, most of these drugs are not appropriate for induction of remission, their early introduction may be helpful in faster tapering of steroids and bridging them to azathioprine or 6-mercaptopurine. In this review the mechanism of action, evidence based therapeutical efficiency and adverse reactions to immunomodulatory drugs will be reviewed.

Original languageSlovenian
Pages (from-to)I29-I35
JournalZdravniski Vestnik
Issue numberSUPPL.1
Publication statusPublished - nov. 18 2013


ASJC Scopus subject areas

  • Medicine(all)

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