Immunological and molecular biological identification of a true case of T‐hairy cell leukaemia

Judith Demeter, Katalin Pálóczi, János Földi, Marianne Hokland, Peter Hokland, Miklós Benczúr, Dezsö Lehoczky

Research output: Article

9 Citations (Scopus)

Abstract

A hairy cell leukaemia (HCL) patient is presented in whom the peripheral blood mononuclear cells (PBMCs) carried suppressor T‐cell markers (CD3 +, CD2 +, CD8 + /CD4‐, CD38 +). Analysis of genomic DNA of PBMNC showed the presence of a monoclonal population of T cells, the T‐cell receptor (TCR) beta‐chain gene being rearranged on both alleles (DR/DR), while the immunoglobulin (Ig) heavy chain‐genes were in germline configuration. The neoplastic cells were found to react with the monoclonal antibody RAB‐1 — originally described as belonging to the B lineage‐restricted monoclonal antibodies — and to carry RAB‐1/CD‐8 in a double marker assay. Natural killer activity of PBMNCs against K562 target cells was severely reduced, while the cells were found to exert strong antibody‐dependent cellular cytotoxicity.

Original languageEnglish
Pages (from-to)339-345
Number of pages7
JournalEuropean journal of haematology
Volume43
Issue number4
DOIs
Publication statusPublished - okt. 1989

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ASJC Scopus subject areas

  • Hematology

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