Abstract
Claudins are key tight junctional proteins between adjacent epithelial, mesothelial or endothelial cells, which are responsible for the permeability of the paracellular space. This paper describes that the endothelial cells of normal hepatic arterioles, portal venules and portal lymphatics as well as the endothelium of sinusoids from dogs show strong membranous claudin-5 cross-reactivity. In 25 liver biopsy samples taken from dogs with portal vein hypoperfusion, an increased number of arterioles was detected in the portal areas (PAs) by the use of humanised anti-claudin-5 antibody. The increased number of hyperplastic hepatic arterioles per PA was 5-6, 8-12 and 15-20 in the case of small, medium-sized and large PAs, respectively. It is suggested that the claudin-5 marker can improve the detection of hepatic arteriolar proliferation in the PAs of liver samples.
| Original language | English |
|---|---|
| Pages (from-to) | 423-430 |
| Number of pages | 8 |
| Journal | Acta Veterinaria Hungarica |
| Volume | 58 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - dec. 1 2010 |
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- veterinary(all)
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Immunohistochemical detection of arteriolar hyperplasia in canine liver biopsy samples using the claudin-5 antibody. / Jakab, Csaba; Rusvai, M.; Gálfi, Péter; Szabára, Ágnes; Szabó, Zoltán; Kulka, J.
In: Acta Veterinaria Hungarica, Vol. 58, No. 4, 01.12.2010, p. 423-430.Research output: Article
}
TY - JOUR
T1 - Immunohistochemical detection of arteriolar hyperplasia in canine liver biopsy samples using the claudin-5 antibody
AU - Jakab, Csaba
AU - Rusvai, M.
AU - Gálfi, Péter
AU - Szabára, Ágnes
AU - Szabó, Zoltán
AU - Kulka, J.
PY - 2010/12/1
Y1 - 2010/12/1
N2 - Claudins are key tight junctional proteins between adjacent epithelial, mesothelial or endothelial cells, which are responsible for the permeability of the paracellular space. This paper describes that the endothelial cells of normal hepatic arterioles, portal venules and portal lymphatics as well as the endothelium of sinusoids from dogs show strong membranous claudin-5 cross-reactivity. In 25 liver biopsy samples taken from dogs with portal vein hypoperfusion, an increased number of arterioles was detected in the portal areas (PAs) by the use of humanised anti-claudin-5 antibody. The increased number of hyperplastic hepatic arterioles per PA was 5-6, 8-12 and 15-20 in the case of small, medium-sized and large PAs, respectively. It is suggested that the claudin-5 marker can improve the detection of hepatic arteriolar proliferation in the PAs of liver samples.
AB - Claudins are key tight junctional proteins between adjacent epithelial, mesothelial or endothelial cells, which are responsible for the permeability of the paracellular space. This paper describes that the endothelial cells of normal hepatic arterioles, portal venules and portal lymphatics as well as the endothelium of sinusoids from dogs show strong membranous claudin-5 cross-reactivity. In 25 liver biopsy samples taken from dogs with portal vein hypoperfusion, an increased number of arterioles was detected in the portal areas (PAs) by the use of humanised anti-claudin-5 antibody. The increased number of hyperplastic hepatic arterioles per PA was 5-6, 8-12 and 15-20 in the case of small, medium-sized and large PAs, respectively. It is suggested that the claudin-5 marker can improve the detection of hepatic arteriolar proliferation in the PAs of liver samples.
KW - Arteriolar hyperplasia
KW - biopsy
KW - claudin-5
KW - dog
KW - immunohistochemistry
KW - liver
UR - http://www.scopus.com/inward/record.url?scp=77955324967&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955324967&partnerID=8YFLogxK
U2 - 10.1556/AVet.58.2010.4.3
DO - 10.1556/AVet.58.2010.4.3
M3 - Article
C2 - 21087912
AN - SCOPUS:77955324967
VL - 58
SP - 423
EP - 430
JO - Acta Veterinaria Hungarica
JF - Acta Veterinaria Hungarica
SN - 0236-6290
IS - 4
ER -