Immune reconstitution: An important component of a successful allogeneic transplantation

Research output: Short survey

14 Citations (Scopus)


The recipients of allogeneic haematopoietic stem cell transplants are characterised by an immunodeficiency of varying severity and duration. Their immunocompromised state is due in part to: (1) an impaired recapitulation of lymphoid ontogeny, (2) a lack of sustained transfer of donor immunity, (3) the effects of graft versus host disease and its therapy, and (4) a reduction in thymic function. Recipients can have delays in the production of naive T lymphocytes following transplantation which result in defects in the production of new antigen specific T lymphocytes and an inability to produce antibodies, especially to carbohydrate antigens. T-cell proliferation as well as immunoglobulin production remains impaired usually until the second half of the first year post-transplant. Other factors that can influence immunological reconstitution include the donor-recipient relationship (histocompatible or matched unrelated donor), intervening infections and recipient age, among others. (C) 2000 Published by Elsevier Science B.V.

Original languageEnglish
Pages (from-to)177-181
Number of pages5
JournalImmunology letters
Issue number3
Publication statusPublished - nov. 1 2000


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this