Lymphocyte transformation, as a cell mediated immune reaction to specific (platelet) and nonspecific (phytohemagglutinin) stimulants has been studied in the lymphocyte cultures of 12 patients suffering from idiopathic thrombocytopenic purpura (ITP) and in that of 10 normal subjects. The platelet antigen induced lymphocyte transformation in a large number of the patients but not in the normal subjects. This is indicative of the cellular immunity which plays a role in the pathomechanism of ITP. The method seems suitable for diagnostic use.
|Number of pages||6|
|Journal||Acta medica Academiae Scientiarum Hungaricae|
|Publication status||Published - dec. 1 1973|
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