Ictal pallor is associated with left temporal seizure onset zone in children

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6 Citations (Scopus)


Purpose: To describe the frequency, localizing and lateralizing value of ictal pallor (IP) in children with focal epilepsy. Methods: A retrospective review of medical charts and 514 archived seizures from 100 children ≤12 years old was performed. All patients had a history of therapy-resistant partial epilepsy and a seizure-free postoperative outcome. The presence and attributes of IP were analyzed. Results: No IP was detected by reviewing the archived seizures. According to medical charts, IP was reported in 11/100 children (six girls) aged 14 months to 12 (mean 5.5 ± 4.1) years. Ten of them had temporal lobe epilepsy (p = 0.046) - including nine temporo-medial and one temporo-lateral cases - while only one child had an extratemporal (parietal lobe) seizure onset zone. All but one children had left-sided operation (p = 0.01). Presence of IP had a positive predictive value of 91% for both lateralizing (left) and localizing (temporal lobe) the seizure onset zone. History of IP was neither age-, epilepsy onset-, nor gender-related. Conclusions: Ictal pallor is a frequently reported autonomic symptom during childhood focal seizures but difficult to assess purely by video-monitoring. It has a high predictive value to localize the seizure onset zone to the left temporal region already in very young patients.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalEpilepsy Research
Issue number3
Publication statusPublished - dec. 2005


ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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