Hypothalamic cell diversity

non-neuronal codes for long-distance volume transmission by neuropeptides

A. Alpár, Marco Benevento, Roman A. Romanov, Tomas Hökfelt, Tibor Harkany

Research output: Review article

1 Citation (Scopus)

Abstract

Volume transmission is a mode of intercellular communication using cerebral liquor to deliver signal molecules over long distances and allow their action for extended periods. For hypothalamic neuropeptides, nerve endings amongst ependymal cells are seen as a site of release into the cerebrospinal fluid. Recent single-cell RNA-seq data identify tanycytes and ventricular ependyma as alternative sources by being unexpectedly rich in neuroactive substances. This notion, coupled with circuit analysis showing regionalized innervation of periventricular ependyma by intrahypothalamic neurons, could allow for the integration of hypothalamic neuronal activity patterns with brain-wide activity changes upon metabolic challenges through phasic volume transmission primed by neuron–ependyma coupling. Here, we discuss emerging data for an ependymal interface and its breaches in neuropsychiatric disease.

Original languageEnglish
Pages (from-to)16-23
Number of pages8
JournalCurrent Opinion in Neurobiology
Volume56
DOIs
Publication statusPublished - jún. 1 2019

Fingerprint

Ependyma
Neuropeptides
Ependymoglial Cells
Nerve Endings
Cerebrospinal Fluid
RNA
Neurons
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hypothalamic cell diversity : non-neuronal codes for long-distance volume transmission by neuropeptides. / Alpár, A.; Benevento, Marco; Romanov, Roman A.; Hökfelt, Tomas; Harkany, Tibor.

In: Current Opinion in Neurobiology, Vol. 56, 01.06.2019, p. 16-23.

Research output: Review article

Alpár, A. ; Benevento, Marco ; Romanov, Roman A. ; Hökfelt, Tomas ; Harkany, Tibor. / Hypothalamic cell diversity : non-neuronal codes for long-distance volume transmission by neuropeptides. In: Current Opinion in Neurobiology. 2019 ; Vol. 56. pp. 16-23.
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