Hypophosphataemiával járó onkogén osteomalacia.

J. Mátyus, B. Szebenyi, P. Rédl, J. Mikita, L. Gáspár, A. Haris, J. Radó, G. Kakuk

Research output: Article

3 Citations (Scopus)

Abstract

The first case of oncogen osteomalacia in Hungary is reported, to draw the attention of the medical profession to it and to present the new data about its pathomechanism. Pathological hip fracture caused by hypophosphataemic osteomalacia due to isolated renal phosphate wasting was found in a previously healthy 19 years old sportsman. In spite of daily 1.5 micrograms calcitriol treatment and phosphate supplementation, hypophosphataemia persisted for 13 years and he needed regular indometacin medication for his bone pain. During that time an 1.5 cm gingival tumour was found and radically removed. The serum phosphate level returned to normal in a few hours after the operation (preoperative 0.51, after 2, 4 and 8 hours 0.61, 0.68 and 0.79 mmol/l respectively), and remained normal without calcitriol. The histological examination showed epulis with fibroblast and vascular cell proliferation, which has never been previously reported in connection with oncogenic osteomalacia. The pain resolved after 3 months and the bone density became normal in one year. Oncogenic osteomalacia must be considered in every case presenting with atypical hypophosphataemic osteomalacia. Careful dental examination is needed also in the course of search for the underlying tumour. Every tumour-like growth, even the common epulis, has to be operated radically and serum phosphate monitored in the postoperative period in all such cases.

Translated title of the contributionHypophosphatemic oncogenic osteomalacia
Original languageHungarian
Pages (from-to)2785-2788
Number of pages4
JournalOrvosi hetilap
Volume141
Issue number51
Publication statusPublished - dec. 17 2000

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Mátyus, J., Szebenyi, B., Rédl, P., Mikita, J., Gáspár, L., Haris, A., Radó, J., & Kakuk, G. (2000). Hypophosphataemiával járó onkogén osteomalacia. Orvosi hetilap, 141(51), 2785-2788.