Hydrothermal synthesis of Sr-doped hydroxyapatite and its antibacterial activity

Teodóra Nagyné-Kovács, Boglárka Mészáros, Mónika Molnár, Mária Tolner, István Endre Lukács, Imre M. Szilágyi, György Pokol

Research output: Article


In this study, we prepared hydroxyapatite (HAP) samples using hydrothermal method. We investigated the effect of reaction conditions such as phosphate excess applying 1.49 and 1.67 (as stoichiometric) Ca/P ratio, pH (9/ 10/ 11/ 12) and time (4/ 8/ 12/ 24 h). Sample characterization was carried out by XRD and SEM. The results showed, all samples had HAP structure, however, lower Ca/P ratio, larger reaction time and setting the pH to 10 increased the crystallinity. Then, we synthetized Sr-doped HAP samples, varying the Sr concentration using 2, 4, 6, 8 and 10 % Sr/ (Ca+Sr). The Sr content was revealed by EDX. Sr-incorporation did not change the obtained crystalline HAP phase but the unit cell parameters increased. We calculated lattice constants and found that a, b changed from 9.4310 Å to 9.4700 Å, c from 6.8819 Å to 6.9227 Å and the unit cell volume from 530.0951 Å3 to 537.6556 Å3 due to the larger ionic radius of Sr compared to Ca. The pure and doped samples had uniform, mostly needle-like morphology with 100-300 nm length and 25-100 nm. In vitro cytotoxicity tests revealed evident antibacterial activity in the case of doped samples compared to pure HAP against E. coli.

Original languageEnglish
Pages (from-to)54-60
Number of pages7
JournalPeriodica Polytechnica Chemical Engineering
Issue number1
Publication statusPublished - jan. 1 2020

ASJC Scopus subject areas

  • Chemical Engineering(all)

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  • Cite this

    Nagyné-Kovács, T., Mészáros, B., Molnár, M., Tolner, M., Lukács, I. E., Szilágyi, I. M., & Pokol, G. (2020). Hydrothermal synthesis of Sr-doped hydroxyapatite and its antibacterial activity. Periodica Polytechnica Chemical Engineering, 64(1), 54-60. https://doi.org/10.3311/PPch.14062