Hydrogenolysis of N-protected aminooxetanes over palladium: An efficient method for a one-step ring opening and debenzylation reaction

Ervin Kovács, Angelika Thurner, Ferenc Farkas, Ferenc Faigl, László Hegeds

Research output: Article

4 Citations (Scopus)

Abstract

An efficient method for the palladium mediated hydrogenation of an optically active, N-protected aminooxetane derivative has been developed. Using appropriate solvents, in a one-step reaction, a chiral 1,4-aminoalcohol derivative [(2S,3R)-4-amino-3-benzoyloxy-2-benzylbutan-1-ol] was formed over a Pd/C catalyst, during hydrogenolytic ring opening and debenzylation reactions.

Original languageEnglish
Pages (from-to)32-36
Number of pages5
JournalJournal of Molecular Catalysis A: Chemical
Volume339
Issue number1-2
DOIs
Publication statusPublished - ápr. 1 2011

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology
  • Physical and Theoretical Chemistry

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