Hydrogenolysis of N- and O-protected hydroxyazetidines over palladium: Efficient and selective methods for ring opening and deprotecting reactions

Ervin Kovács, Ferenc Faigl, Zoltán Mucsi, Miklós Nyerges, László Hegedus

Research output: Article

2 Citations (Scopus)

Abstract

Some N- and O-protected hydroxyazetidine derivatives were hydrogenated to the corresponding amines or aminoalcohols over a Pd/C catalyst, in different solvents (methanol, dichloromethane, tetrahydrofuran), at 30-60 °C and 1-10 bar. These amino compounds, formed during hydrogenolytic ring opening and/or deprotecting reactions, are potential starting materials for preparing optically active, practically important pyrrolidine derivatives.

Original languageEnglish
Pages (from-to)217-224
Number of pages8
JournalJournal of Molecular Catalysis A: Chemical
Volume395
DOIs
Publication statusPublished - dec. 2014

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology
  • Physical and Theoretical Chemistry

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